苯磷硫胺对雄性大鼠胃溃疡的保护作用:一项实验研究。

IF 2.9 4区 生物学 Q3 CELL BIOLOGY
Mohammad Shokati Sayyad, Mohammad Hossein Khanjani, Milad Amirbeik, Mohammad Seyedabadi, Fereshteh Talebpour Amiri, Vida Motamednia, Nastaran Rezaei, Fatemeh Shaki
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引用次数: 0

摘要

胃溃疡是一种常见的胃肠道疾病,发病率和死亡率都很高。它还会增加罹患胃癌的风险。本研究旨在探讨苯磷硫胺对实验诱导的雄性大鼠胃溃疡的影响。本研究将30只Wistar雄性大鼠随机分为六组:对照组(正常)、吲哚美辛组、奥美拉唑组和治疗组(包括每公斤50、100和200毫克的苯磷硫胺)。吲哚美辛灌胃诱发胃溃疡。连续三天服用奥美拉唑和不同治疗剂量的苯磷硫胺。结果表明,每公斤 100 毫克和 200 毫克的苯磷硫胺能明显改善吲哚美辛引起的胃组织损伤。此外,100和200毫克/千克的苯磷硫胺能有效降低促炎细胞因子IL-6和TNF-α以及氧化应激标志物MDA和ROS的水平,同时提高抗氧化剂GSH的水平。这些研究结果表明,苯磷硫胺的胃保护作用是通过其抗氧化和抗炎特性介导的,这有助于减轻与吲哚美辛诱导的胃溃疡相关的组织损伤和炎症反应。然而,还需要进一步的研究来阐明这些有益作用的确切分子机制,并评估苯磷硫胺在临床中的潜在治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study

The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study

The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study

Gastric ulcers are a common gastrointestinal disorder associated with significant morbidity and mortality. It can also increase the risk of gastric cancer. This study aimed to investigate the effect of benfotiamine on experimentally-induced gastric ulcers in male rats. In this study, 30 Wistar male rats were divided randomly into six groups: control (normal), indomethacin, omeprazole, and treatment groups, including 50, 100, and 200 mg/kg of benfotiamine. Gastric ulcer was induced by indomethacin gavage. Omeprazole and different therapeutic doses of benfotiamine were administered for three days. Twenty-four hours after the last treatment, the rats were euthanized, and samples were collected.

The results demonstrated that 100 and 200 mg/kg of benfotiamine treatment significantly improved indomethacin-induced gastric tissue damage. Moreover, benfotiamine at 100 and 200 mg/kg effectively attenuated the levels of pro-inflammatory cytokines IL-6 and TNF-α and oxidative stress markers MDA and ROS while increasing the antioxidant GSH. These findings suggest that benfotiamine’s gastroprotective effects are mediated through its antioxidant and anti-inflammatory properties, which help mitigate the tissue damage and inflammatory response associated with indomethacin-induced gastric ulcers.

However, further research is needed to elucidate the precise molecular mechanisms underlying these beneficial effects and to evaluate the potential therapeutic application of benfotiamine in clinical settings.

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来源期刊
Journal of Molecular Histology
Journal of Molecular Histology 生物-细胞生物学
CiteScore
5.90
自引率
0.00%
发文量
68
审稿时长
1 months
期刊介绍: The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.
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