{"title":"基于β-环糊精和磷胆碱的具有长T2弛豫时间的超支化聚合物19F磁共振成像对比剂。","authors":"Jialei Han, Ziwei Duan, Changjiang Liu, Yadong Liu, Xinyu Zhao, Bo Wang, Shuaishuai Cao, Dalin Wu","doi":"10.1021/acs.biomac.4c00548","DOIUrl":null,"url":null,"abstract":"<p><p><sup>19</sup>F magnetic resonance imaging (<sup>19</sup>F MRI) is gaining attention as an emerging diagnostic technology. Effective <sup>19</sup>F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin-spin) relaxation time (<i>T</i><sub>2</sub>), short longitudinal (or spin-lattice) relaxation time (<i>T</i><sub>1</sub>), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric <sup>19</sup>F MRI CA based on β-cyclodextrin and phosphorylcholine. The influence of the branching degree and fluorine content on <i>T</i><sub>2</sub> was thoroughly investigated. Results demonstrated a maximum fluorine content of 11.85% and a <i>T</i><sub>2</sub> of 612 ms. This hyperbranched polymeric <sup>19</sup>F MRI CA exhibited both great biocompatibility against cells and organs of mice and high-performance imaging capabilities both in vitro and in vivo. The research provides positive insights into the synthesis strategies, topological design, and selection of fluorine tags for <sup>19</sup>F MRI CAs.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"5860-5872"},"PeriodicalIF":5.4000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hyperbranched Polymeric <sup>19</sup>F MRI Contrast Agents with Long <i>T</i><sub>2</sub> Relaxation Time Based on β-Cyclodextrin and Phosphorycholine.\",\"authors\":\"Jialei Han, Ziwei Duan, Changjiang Liu, Yadong Liu, Xinyu Zhao, Bo Wang, Shuaishuai Cao, Dalin Wu\",\"doi\":\"10.1021/acs.biomac.4c00548\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><sup>19</sup>F magnetic resonance imaging (<sup>19</sup>F MRI) is gaining attention as an emerging diagnostic technology. Effective <sup>19</sup>F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin-spin) relaxation time (<i>T</i><sub>2</sub>), short longitudinal (or spin-lattice) relaxation time (<i>T</i><sub>1</sub>), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric <sup>19</sup>F MRI CA based on β-cyclodextrin and phosphorylcholine. The influence of the branching degree and fluorine content on <i>T</i><sub>2</sub> was thoroughly investigated. Results demonstrated a maximum fluorine content of 11.85% and a <i>T</i><sub>2</sub> of 612 ms. This hyperbranched polymeric <sup>19</sup>F MRI CA exhibited both great biocompatibility against cells and organs of mice and high-performance imaging capabilities both in vitro and in vivo. The research provides positive insights into the synthesis strategies, topological design, and selection of fluorine tags for <sup>19</sup>F MRI CAs.</p>\",\"PeriodicalId\":30,\"journal\":{\"name\":\"Biomacromolecules\",\"volume\":\" \",\"pages\":\"5860-5872\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomacromolecules\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.biomac.4c00548\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomacromolecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.biomac.4c00548","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/7 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Hyperbranched Polymeric 19F MRI Contrast Agents with Long T2 Relaxation Time Based on β-Cyclodextrin and Phosphorycholine.
19F magnetic resonance imaging (19F MRI) is gaining attention as an emerging diagnostic technology. Effective 19F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin-spin) relaxation time (T2), short longitudinal (or spin-lattice) relaxation time (T1), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric 19F MRI CA based on β-cyclodextrin and phosphorylcholine. The influence of the branching degree and fluorine content on T2 was thoroughly investigated. Results demonstrated a maximum fluorine content of 11.85% and a T2 of 612 ms. This hyperbranched polymeric 19F MRI CA exhibited both great biocompatibility against cells and organs of mice and high-performance imaging capabilities both in vitro and in vivo. The research provides positive insights into the synthesis strategies, topological design, and selection of fluorine tags for 19F MRI CAs.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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