用线性聚（乙烯亚胺）改性的乳酸低聚物用于抗菌涂层

IF 3.9 2区化学 Q2 POLYMER SCIENCE

Polymer Chemistry Pub Date : 2024-09-10 DOI:10.1039/d4py00605d

Anna Iuliano , Maksymilian Kukuć , Julita Pachla , Dominik Jańczewski , Jolanta Mierzejewska , Karolina Drężek

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引用次数: 0

摘要

在缩水甘油存在下，通过开环溶液聚合合成了内酰胺低聚物，并将其用于与线性聚乙烯亚胺（L-PEI）的加成反应。使用 1H NMR、GPC 和 MALDI TOF 对内酰胺低聚物进行了详细分析。不同分子量（2.5 和 4.0 kg mol-1）的 L-PEI 被引入到与内酯低聚物的加成反应中。用各种 1-溴烷烃对得到的共聚物进行改性，并研究了它们的接枝率以及最终产品对大肠杆菌的抗菌性能。无论使用的 L-PEI：PLA 的比例如何，在溴丁烷存在下获得的接枝水平最高的产品，无论是作为聚合物薄膜还是与商用聚乳酸共混，都显示出了强大的抗菌活性。当聚乳酸混合物中 1-溴辛烷和 1-溴癸烷接枝共聚物的浓度为 30 wt%时，细菌生长受到抑制。在这种情况下，混合物中 PEI 的总重量为 1.1%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lactide oligomers modified with linear polyethyleneimine for antibacterial coatings†

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Lactide oligomers modified with linear polyethyleneimine for antibacterial coatings†

Lactide oligomers were synthesized in the presence of glycidol via ring opening solution polymerization and used in the addition reaction with linear polyethyleneimine (L-PEI). Detailed analysis of the lactide oligomers was conducted using ¹H NMR, GPC and MALDI-ToF. L-PEI with different molecular weight (2.5 and 4.0 kg mol⁻¹) was introduced to the addition reaction with lactide oligomers. The obtained copolymers were modified with various 1-bromoalkanes and their percentage of grafting as well as antibacterial properties of the final product against Escherichia coli were studied. The product with the highest grafting level was obtained in the presence of bromobutane, regardless of the L-PEI : PLA ratio used, and displayed potent antimicrobial activity both as a polymer film and in the blend with commercial polylactide. Inhibition of bacterial growth was observed at a concentration of 30 wt% of the copolymer grafted with 1-bromooctane and 1-bromodecane in the polylactide blend. In this case the total wt% of PEI in the blend was 1.1%.

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来源期刊

Polymer Chemistry POLYMER SCIENCE-

CiteScore

8.60

自引率

8.70%

发文量

535

审稿时长

1.7 months

期刊介绍： Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.