印度首次爆发腺肠病毒结膜炎的临床观察和实时 PCR 分析:一项全面的横断面研究。

Journal of postgraduate medicine Pub Date : 2024-07-01 Epub Date: 2024-08-07 DOI:10.4103/jpgm.jpgm_256_24
A Aishwarya, R Agarwal, A Garg, V Jain
{"title":"印度首次爆发腺肠病毒结膜炎的临床观察和实时 PCR 分析:一项全面的横断面研究。","authors":"A Aishwarya, R Agarwal, A Garg, V Jain","doi":"10.4103/jpgm.jpgm_256_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study aimed to investigate the emergence of adeno-enterovirus conjunctivitis, with a focus on its clinical manifestations, prevalence, and implications within the context of acute epidemic conjunctivitis.</p><p><strong>Methods: </strong>Real-time PCR analysis was employed to precisely identify the viral strain in conjunctival swab samples. A total of 80 patients were tested, and specific clinical symptoms were assessed.</p><p><strong>Results: </strong>The study revealed the first documented case in India and the second worldwide of adeno-enterovirus conjunctivitis. The prevalence among the tested patients was significant, with 15% testing positive. Those infected with adeno-enterovirus exhibited shorter illnesses (≤3 days). Notably, clinical symptoms such as subconjunctival hemorrhage, chemosis, swelling, photophobia, and epiphora were significantly linked to this viral variant. Multivariable logistic regression analysis highlighted swelling and photophobia as robust predictors for identifying adeno-enterovirus conjunctivitis cases.</p><p><strong>Conclusion: </strong>The findings underscore the urgent need to recognize adeno-enterovirus conjunctivitis as a potential threat, capable of causing significant ocular morbidity. Swelling and photophobia emerged as robust predictors for identifying cases, emphasizing the importance of vigilant monitoring and comprehension of this viral variant. Proactive measures are essential to address its clinical implications and mitigate its impact on affected populations. Ongoing research is crucial to unravel the complete spectrum of adeno-enterovirus conjunctivitis and guide effective management strategies.</p>","PeriodicalId":94105,"journal":{"name":"Journal of postgraduate medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458071/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical insights and real-time PCR analysis of the first adeno-enterovirus conjunctivitis outbreak in India: A comprehensive cross-sectional study.\",\"authors\":\"A Aishwarya, R Agarwal, A Garg, V Jain\",\"doi\":\"10.4103/jpgm.jpgm_256_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This cross-sectional study aimed to investigate the emergence of adeno-enterovirus conjunctivitis, with a focus on its clinical manifestations, prevalence, and implications within the context of acute epidemic conjunctivitis.</p><p><strong>Methods: </strong>Real-time PCR analysis was employed to precisely identify the viral strain in conjunctival swab samples. A total of 80 patients were tested, and specific clinical symptoms were assessed.</p><p><strong>Results: </strong>The study revealed the first documented case in India and the second worldwide of adeno-enterovirus conjunctivitis. The prevalence among the tested patients was significant, with 15% testing positive. Those infected with adeno-enterovirus exhibited shorter illnesses (≤3 days). Notably, clinical symptoms such as subconjunctival hemorrhage, chemosis, swelling, photophobia, and epiphora were significantly linked to this viral variant. Multivariable logistic regression analysis highlighted swelling and photophobia as robust predictors for identifying adeno-enterovirus conjunctivitis cases.</p><p><strong>Conclusion: </strong>The findings underscore the urgent need to recognize adeno-enterovirus conjunctivitis as a potential threat, capable of causing significant ocular morbidity. Swelling and photophobia emerged as robust predictors for identifying cases, emphasizing the importance of vigilant monitoring and comprehension of this viral variant. Proactive measures are essential to address its clinical implications and mitigate its impact on affected populations. Ongoing research is crucial to unravel the complete spectrum of adeno-enterovirus conjunctivitis and guide effective management strategies.</p>\",\"PeriodicalId\":94105,\"journal\":{\"name\":\"Journal of postgraduate medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458071/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of postgraduate medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jpgm.jpgm_256_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of postgraduate medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jpgm.jpgm_256_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/7 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

研究目的这项横断面研究旨在调查腺肠病毒结膜炎的出现,重点是其临床表现、流行率以及对急性流行性结膜炎的影响:方法:采用实时 PCR 分析法精确鉴定结膜拭子样本中的病毒株。共对 80 名患者进行了检测,并对具体临床症状进行了评估:结果:该研究发现了印度首例、全球第二例腺肠病毒结膜炎病例。接受检测的患者中发病率很高,15%呈阳性。腺肠病毒感染者的病程较短(≤3 天)。值得注意的是,结膜下出血、化脓、肿胀、畏光和外窥等临床症状与这种病毒变体有明显联系。多变量逻辑回归分析强调,肿胀和畏光是识别腺肠病毒结膜炎病例的有力预测因素:结论:研究结果表明,我们迫切需要认识到腺肠病毒性结膜炎是一种潜在威胁,可导致严重的眼部疾病。肿胀和畏光是确定病例的有力预测因素,这强调了警惕监测和了解这种病毒变体的重要性。必须采取积极主动的措施来应对其临床影响并减轻其对受影响人群的影响。持续的研究对于揭示腺肠病毒结膜炎的全貌和指导有效的管理策略至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical insights and real-time PCR analysis of the first adeno-enterovirus conjunctivitis outbreak in India: A comprehensive cross-sectional study.

Objective: This cross-sectional study aimed to investigate the emergence of adeno-enterovirus conjunctivitis, with a focus on its clinical manifestations, prevalence, and implications within the context of acute epidemic conjunctivitis.

Methods: Real-time PCR analysis was employed to precisely identify the viral strain in conjunctival swab samples. A total of 80 patients were tested, and specific clinical symptoms were assessed.

Results: The study revealed the first documented case in India and the second worldwide of adeno-enterovirus conjunctivitis. The prevalence among the tested patients was significant, with 15% testing positive. Those infected with adeno-enterovirus exhibited shorter illnesses (≤3 days). Notably, clinical symptoms such as subconjunctival hemorrhage, chemosis, swelling, photophobia, and epiphora were significantly linked to this viral variant. Multivariable logistic regression analysis highlighted swelling and photophobia as robust predictors for identifying adeno-enterovirus conjunctivitis cases.

Conclusion: The findings underscore the urgent need to recognize adeno-enterovirus conjunctivitis as a potential threat, capable of causing significant ocular morbidity. Swelling and photophobia emerged as robust predictors for identifying cases, emphasizing the importance of vigilant monitoring and comprehension of this viral variant. Proactive measures are essential to address its clinical implications and mitigate its impact on affected populations. Ongoing research is crucial to unravel the complete spectrum of adeno-enterovirus conjunctivitis and guide effective management strategies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信