2013-2022 年意大利一家生产含氟聚合物的化工企业工人血清中 PFOA、ADV 和 cC6O4 对生化和血液学的影响。

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES
Dario Consonni , Silvia Fustinoni
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引用次数: 0

摘要

导言:全氟烷基和多氟烷基物质(PFAS)广泛用于氟聚合物的生产。我们对一家含氟聚合物公司的工人血清中的全氟辛酸(PFOA)、ADV和cC6O4这三种PFAS的生化和血液学影响进行了评估:利用数据(2013-2022 年),我们建立了随机截距回归模型,并对几个协变量和三种 PFAS 之间的相互调整进行了调整:我们分析了 814 名工人(698 名男性,116 名女性)的数据,其中 607 人来自化工厂,207 人来自研究中心,共采集了 4912 份血液样本(其中 2065 份测量了所有三种 PFAS)。PFOA 和 ADV 的中位含量分别为 21.3 微克/升和 120 微克/升。大多数(65.5%)cC6O4 测量值低于定量限(随时间变化,从 5 微克/升到 0.1 微克/升不等)。就全氟辛酸而言,我们观察到与总胆固醇(ln(PFOA)每增加1.1%)和脂蛋白B(+1.4%)呈正相关,而与碱性磷酸酶(-1.5%)呈负相关;还发现与红细胞(-0.4%)、IgA(-1.5%)和IgM(-1.4%)呈提示性相关。ADV 与总胆固醇和低密度脂蛋白胆固醇(ln(ADV)每增加 +1.0% 和 +1.6%)、载脂蛋白 B(+1.0%)、谷氨酰转肽酶(+2.1%)、IgM(+1.4%)和白细胞(+1.5%)呈负相关,与直接胆红素(-2.3%)和甲型 2-球蛋白(-0.7%)呈负相关;间接胆红素(-2.0%)、雌二醇(-2.1%)和 CRP(+6.0%)呈提示性相关。在可检测到 cC6O4 水平的样本中,我们观察到 ALP(+2.3%)、蛋白质(+0.5%)、IgG(+0.7%)和血小板(+1.6%)的值较高,总胆红素(+3.9%)、红细胞(+0.6%)和雌二醇(+5.8%)的值也有提示性升高。一些关联(总胆固醇、脂蛋白 B、白细胞、总胆红素和碱性磷酸酶)与血清全氟辛酸和 ADV 在研究期间的大幅下降呈反向时间趋势:讨论:我们发现血清 PFOA 和 ADV 与脂质代谢、肝功能和免疫球蛋白有关。一些终点的反向时间趋势与血清 PFOA 和 ADV 的下降平行,这加强了对结果的因果解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biochemical and haematological effects of serum PFOA, ADV and cC6O4 in workers of a chemical company producing fluoropolymers, Italy, 2013–2022

Introduction

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in the manufacture of fluoropolymers. We evaluated biochemical and haematological effects of three PFAS, serum perfluorooctanoic acid (PFOA), ADV, and cC6O4 in workers of a fluoropolymer company.

Methods

Using data (2013–2022), we fitted random intercept regression models adjusted for several covariates and reciprocal adjustment between the three PFAS.

Results

We analysed data of 814 workers (698 men, 116 women), 607 from the chemical plant, 207 from the research centre, for a total of 4912 blood samples (2065 with all three PFAS measured). Median levels of PFOA and ADV were 21.3 and 120 μg/L. Most (65.5%) cC6O4 measurements were below the limits of quantification (which varied over time from 5 to 0.1 μg/L). For PFOA, we observed positive associations with total cholesterol (+1.1% increase per ln(PFOA) increase) and apolipoprotein B (+1.4%) and negative associations with alkaline phosphatase (−1.5%); suggestive associations were also found with RBC (−0.4%), IgA (−1.5%), IgM (−1.4%). ADV was positively associated with total and LDL cholesterol (+1.0% and +1.6% per ln(ADV) increase), apolipoprotein B (+1.0%), GGT (+2.1%), IgM (+1.4%), and WBC (+1.5%) and negatively associated with direct bilirubin (−2.3%) and alpha-2-globulins (−0.7%); suggestive associations were found for indirect bilirubin (−2.0%), oestradiol (−2.1%), ad CRP (+6.0%). For samples with detectable cC6O4 levels we observed higher values of ALP (+2.3%), proteins (+0.5%), IgG (+0.7%) and platelets (+1.6%) and suggestively increased total bilirubin (+3.9%), RBC (+0.6%), and oestradiol (+5.8%). Some associations (total cholesterol, apolipoprotein B, WBC, total bilirubin, and alkaline phosphatase showed reverse time trends in parallel with the strong decrease of serum PFOA and ADV over the study period.

Discussion

We found associations of serum PFOA and ADV with lipid metabolism, liver function, and immunoglobulins. The reverse time trends of some endpoints in parallel with decrease of serum PFOA and ADV reinforce causal interpretation of results. cC6O4 showed a different pattern of associations.

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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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