血清皮质醇和神经质对肢体损伤患者两年内创伤后应激障碍的影响。

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY
Psychiatry and Clinical Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-08-07 DOI:10.1111/pcn.13718
Jae-Min Kim, Hee-Ju Kang, Ju-Wan Kim, Hyunseok Jang, Jung-Chul Kim, Byung Jo Chun, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin
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引用次数: 0

摘要

目的:本研究旨在探讨血清皮质醇水平、人格特质与肢体受伤者两年内创伤后应激障碍(PTSD)发展之间的关系:从创伤中心连续招募参与者,并对其进行为期两年的前瞻性跟踪调查。在基线时,测量血清皮质醇水平,并使用大五量表-10 将人格特质分为五个维度(外向性、宜人性、自觉性、神经质和开放性)。在随访期间(受伤后 3、6、12 和 24 个月),创伤后应激障碍的诊断是使用 DSM-5 临床医师管理创伤后应激障碍量表确定的。对皮质醇水平、人格特质和创伤后应激障碍发展之间的相互作用进行了二元和多叉逻辑回归分析:在接受分析的 923 名患者中,有 112 人(12.1%)在研究期间的某个阶段被诊断为创伤后应激障碍,患病率从受伤后 3 个月时的 8.8% 降至受伤后 24 个月时的 3.7%。皮质醇水平或人格特质与创伤后应激障碍之间没有直接关联。然而,在皮质醇水平较低和神经质较高之间发现了一种与创伤后应激障碍风险之间的重要交互作用,尤其是在早期随访期间(3至6个月),但从12个月的随访开始,这种关联逐渐减弱:我们的研究结果表明,血清皮质醇水平与创伤后应激障碍的发展之间存在神经质依赖关系,并表现出时间变化。这些结果表明,创伤后应激障碍的发展可能受到复杂的、对时间敏感的生物和社会心理因素相互作用的影响,这突出了在创伤后应激障碍的研究和治疗中考虑应激反应性和人格的个体差异的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum cortisol and neuroticism for post-traumatic stress disorder over 2 years in patients with physical injuries.

Aim: This study aimed to explore the relationships between serum cortisol levels, personality traits, and the development of Post-Traumatic Stress Disorder (PTSD) over 2 years among individuals with physical injuries.

Methods: Participants were consecutively recruited from a trauma center and followed prospectively for 2 years. At baseline, serum cortisol levels were measured, and personality traits were categorized into five dimensions (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness), using the Big Five Inventory-10. The diagnosis of PTSD during follow-up (at 3, 6, 12, and 24 months post-injury) was determined using the Clinician-Administered PTSD Scale for DSM-5. Binary and multinomial logistic regression analyses were conducted to examine the interactions between cortisol levels, personality traits, and PTSD development.

Results: Among 923 patients analyzed, 112 (12.1%) were diagnosed with PTSD at some point during the study period, with prevalence rates decreasing from 8.8% at 3 months to 3.7% at 24 months post-injury. Direct associations between cortisol levels or personality traits and PTSD were not observed. However, a significant interaction between lower cortisol levels and higher Neuroticism in relation to PTSD risk was identified, especially during the early follow-up periods (3 to 6 months), but this association waned from the 12-month follow-up onward.

Conclusion: Our findings reveal Neuroticism-dependent associations between serum cortisol levels and PTSD development, exhibiting temporal variations. These results suggest that PTSD development may be influenced by a complex, time-sensitive interplay of biological and psychosocial factors, underscoring the importance of considering individual differences in stress reactivity and personality in PTSD research and treatment.

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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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