慢性疼痛与工作记忆的更新特别相关:一项纵向双胞胎研究。

IF 5.9 1区 医学 Q1 ANESTHESIOLOGY
PAIN® Pub Date : 2025-01-01 Epub Date: 2024-08-06 DOI:10.1097/j.pain.0000000000003347
Lydia Rader, Tor D Wager, Naomi P Friedman
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引用次数: 0

摘要

摘要:较差的执行功能(EF)与慢性疼痛有关,并可能从机制上导致疼痛慢性化。目前尚不清楚执行功能是否存在整体损伤,还是在特定认知领域存在损伤。此外,这些关联背后可能存在的遗传风险也尚未得到检测。参与者来自科罗拉多纵向双胞胎研究;786对同性双胞胎在23岁和/或28岁时完成了一系列EF任务,其中634对双胞胎在平均年龄=28.1岁时使用简短疼痛史问卷自我报告了慢性疼痛;患病率=27.76%。EF 任务被用来定义一个通用 EF 因子和两个专门用于更新工作记忆和转换思维定势的因子。我们估算了 23 岁和 28 岁稳定 EF 变异的表型和遗传关联,以及 28 岁特有的 EF 变异与疼痛的关联。在稳定的 EF 变异方面,疼痛与更新特异因子存在表型相关性(r = -0.21,P = 0.008),但与普通 EF 因子(r = -0.06,P = 0.350)或转移特异因子(r = -0.03,P = 0.709)无显著相关性。疼痛与 28 岁特有的 EF 变异之间没有明显的表型相关性。双生子模型表明,疼痛和更新特异性变异具有遗传风险(rA = -0.46,P = 0.005),但不具有环境风险(rE = 0.05,P = 0.844)。更新工作记忆与青壮年疼痛具有表型和遗传关系。门控或监测疼痛信号的障碍可能在疼痛的发展过程中起着机理作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic pain is specifically associated with updating working memory: a longitudinal twin study.

Abstract: Worse executive function (EF) is associated with chronic pain and could mechanistically contribute to pain chronification. It is unclear whether there is overall impairment in EFs or whether there are impairments in specific cognitive domains. Furthermore, the possible genetic risk underlying these associations has not been tested. Participants were from the Colorado Longitudinal Twin study; 786 same-sex twins completed a battery of EF tasks at ages 23 and/or 28 and 634 of these twins self-reported chronic pain at mean age = 28.1; prevalence = 27.76% using the Brief Pain History Questionnaire. The EF tasks were used to define a Common EF factor and 2 factors specific to updating working memory and shifting mental set. We estimated the phenotypic and genetic associations of stable EF variance across ages 23 and 28, as well as EF variance unique to age 28, with pain. With respect to stable EF variance, pain phenotypically correlated with the Updating-specific factor ( r = -0.21, P = 0.008) but did not significantly correlate with the Common EF factor ( r = -0.06, P = 0.350) nor with the Shifting-specific factor ( r = -0.03, P = 0.709). There were no significant phenotypic correlations between pain and EF variance unique to age 28. A twin model indicated that pain and Updating-specific variance share genetic risk ( r A = -0.46, P = 0.005) but not environmental risk ( r E = 0.05, P = 0.844). Updating working memory shares a phenotypic and genetic relationship with pain in young adults. Impairments in gating or monitoring pain signals may play a mechanistic role in pain development.

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来源期刊
PAIN®
PAIN® 医学-临床神经学
CiteScore
12.50
自引率
8.10%
发文量
242
审稿时长
9 months
期刊介绍: PAIN® is the official publication of the International Association for the Study of Pain and publishes original research on the nature,mechanisms and treatment of pain.PAIN® provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
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