中国 H 型高血压患者的同型半胱氨酸水平与糖尿病有关。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition Research and Practice Pub Date : 2024-08-01 Epub Date: 2024-05-27 DOI:10.4162/nrp.2024.18.4.511
Dejian Fu, Wanbao Gong, Xiaomin Bao, Bo Yang, Feng Wang, Yubing Qiao, Yuanjiang Wu, Guangzhen Chen, Weixun Sun, Qiongzhi Xiao, Wenbo Zou, Ning Fang
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引用次数: 0

摘要

背景/目的该研究探讨了H型高血压患者同型半胱氨酸与糖尿病之间的关系,并评估了可能的效应调节因素:这项横断面研究纳入了 "H型高血压管理与脑卒中预防战略国际科技创新合作项目 "中1255名符合条件的中国农村H型高血压患者。研究采用多变量逻辑回归模型评估同型半胱氨酸与糖尿病之间的关系:结果:糖尿病患者总同型半胱氨酸(tHcy)的平均水平为 19.37 μmol/L,明显高于非糖尿病患者(18.18 μmol/L)。当将 tHcy 作为连续变量进行分析时,糖尿病的几率比(OR)为 1.17(95% 置信区间 [CI],1.01-1.35;每四分位数区间)。如果根据五分位数对 tHcy 进行分层,与参照组(tHcy < 12.04 μmol/L)相比,最高五分位数(tHcy ≥ 20.60 μmol/L)的糖尿病几率比为 2.86(95% 置信区间 [CI],1.22-6.69)。当 tHcy 按 15 μmol/L 和 20 μmol/L 分组时,tHcy ≥ 20 μmol/L 的患者患糖尿病的风险(OR,2.03;95% CI,1.04-3.96)显著高于 tHcy < 15 μmol/L 的患者(P = 0.037)。分组分析表明,tHcy与糖尿病的关系不受其他变量的影响:在这项针对中国农村 H 型高血压患者的研究中,tHcy 水平与糖尿病呈正相关。结论:在这项研究中,中国农村 H 型高血压患者的 tHcy 水平与糖尿病呈正相关,这种独立的关联不受其他潜在风险因素的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Homocysteine levels are associated with diabetes mellitus in Chinese with H-type hypertension.

Background/objectives: The study examined the association between homocysteine and diabetes mellitus in patients with H-type hypertension and assessed the possible effect modifiers.

Subjects/methods: This cross-sectional study included 1,255 eligible participants in the 'H-type Hypertension Management and Stroke Prevention Strategic International Science and Technology Innovation Cooperation Project' among rural Chinese people with H-type hypertension. A multivariate logistic regression model was used to evaluate the relationship between homocysteine and diabetes mellitus.

Results: The mean level of total homocysteine (tHcy) in the diabetes mellitus population was 19.37 μmol/L, which was significantly higher than the non-diabetic patients (18.18 μmol/L). When tHcy was analyzed as a continuous variable, the odds ratio (OR) of diabetes was 1.17 (95% confidence interval [CI], 1.01-1.35; per interquartile range). When tHcy was stratified according to the quintile, the ORs for diabetes were 2.86 (95% CI, 1.22-6.69) in the highest quintile (tHcy ≥ 20.60 μmol/L) compared to the reference group (tHcy < 12.04 μmol/L). When tHcy was grouped by 15 μmol/L and 20 μmol/L, patients with tHcy ≥ 20 μmol/L had a significantly (P = 0.037) higher risk of diabetes (OR, 2.03; 95% CI, 1.04-3.96) than in those with tHcy < 15 μmol/L. Subgroup analysis showed that the tHcy-diabetes association was unaffected by other variables.

Conclusion: In this study of rural Chinese people with H-type hypertension, the tHcy levels showed a positive association with diabetes mellitus. This independent association is unaffected by other potential risk factors.

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来源期刊
Nutrition Research and Practice
Nutrition Research and Practice NUTRITION & DIETETICS-
CiteScore
3.50
自引率
4.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010. NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.
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