产前重金属暴露与小儿哮喘、过敏性鼻炎和特应性皮炎：系统回顾和荟萃分析。

IF 3.9 3区医学 Q2 IMMUNOLOGY

Expert Review of Clinical Immunology Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI:10.1080/1744666X.2024.2390024

Xi Chen, Shipeng Zhang, Dongxi Jiang, Yu Li, Man Yin, Caishan Fang, Zeyi Lv, Yue Huang, Hao Yang, Hui Zhang, Jianfeng Zhang, Qinwei Fu, Hanyu Wang, Wenjing Jiang, Yang Chen, Xinrong Li

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引用次数: 0

摘要

目的我们回顾了产前暴露于重金属的儿童过敏性疾病的发病率：本系统综述和荟萃分析已在 PROSPERO 数据库（CRD42023478471）中注册。从数据库建立到 2023 年 10 月 31 日，对 PubMed、Web of Science、Medline 和 Cochrane 图书馆进行了全面检索。采用纽卡斯尔-渥太华质量评估量表（NOS）评估纳入研究的质量。我们采用随机效应模型来总结研究的效果：共纳入 16 项研究，120,065 对母婴参加了研究。NOS评分表明，纳入研究的文献质量较高：最终结果表明，产前接触铅会增加婴儿喘息和湿疹的发病率，接触镍和CD会增加婴儿注意力缺失症的发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prenatal heavy metal exposure and pediatric asthma, allergic rhinitis, atopic dermatitis: a systematic review and meta-analysis.

Objective: We review the prevalence of allergic diseases in children across prenatal exposures to heavy metals.

Methods: This systematic review and meta-analysis is registered in the PROSPERO database (CRD42023478471). A comprehensive search of PubMed, Web of Science, Medline and Cochrane library was conducted from the database inception until 31 October 2023. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to assess the quality of included studies. We used a random-effects model to summarize the effects from the studies.

Results: A total of 16 studies were included, 120,065 mother-child pairs enrolled. The NOS scores indicated that the quality of the literature included in the study was of a high standard.

Conclusion: The final results indicate that prenatal exposure to Pb increased the incidence of wheeze and Eczema in infants, and exposure to Ni and CD increased the incidence of AD in infants.

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来源期刊

Expert Review of Clinical Immunology IMMUNOLOGY-

CiteScore

7.60

自引率

2.30%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.