瑞典全国样本中的同伴社会遗传效应与药物使用障碍、重度抑郁症和焦虑症的病因。

IF 15.1 1区 医学 Q1 PSYCHIATRY
American Journal of Psychiatry Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI:10.1176/appi.ajp.20230358
Jessica E Salvatore, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler
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引用次数: 0

摘要

目的:人们越来越关注同伴的基因型如何影响健康(即同伴社会遗传效应)。作者试图阐明同伴社会遗传效应对药物使用障碍、酒精使用障碍(AUD)、重度抑郁症和焦虑症风险的影响:方法:利用瑞典人群队列(N=655,327)的数据建立了 Cox 模型。结果是 17 岁至 30 岁期间从医疗、刑事和药房登记处登记的吸毒障碍、AUD、重度抑郁和焦虑症。作者将同龄人的社会遗传效应与同龄人的家族遗传风险评分(FGRSs)进行了指数化,后者是根据一至五代亲属的诊断结果推断出的遗传风险的个性化测量方法:在各种疾病中,同辈人的家族遗传风险评分可预测原告登记的风险增加(危险比范围为 1.01-1.59),对吸毒障碍和 AUD 的影响强于对重度抑郁症和焦虑症的影响。同龄人的社会遗传效应对学校同学的影响比对地理位置相近的同龄人的影响更大,对高中(16-19 岁)同龄人的影响比对初中(7-16 岁)同龄人的影响更大。在对社会人口混杂因素、同龄人是否受影响以及同龄人受教育程度的 FGRS 进行统计控制后,同龄人的社会遗传效应仍然显著。对于遗传风险较高的受试者,同伴的社会遗传效应更为明显:青少年同伴的遗传构成对吸毒障碍、AUD、重度抑郁症和焦虑症的风险具有深远影响。高遗传风险个体对社会遗传效应更为敏感。其他假设,如社会人口分层、接触受影响的同龄人以及受教育程度的遗传倾向,都无法解释同龄人社会遗传效应对药物使用和精神障碍的相关风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample.

Objective: There is growing interest in how peers' genotypes may influence health (i.e., peer social genetic effects). The authors sought to clarify the nature of peer social genetic effects on risk for drug use disorder, alcohol use disorder (AUD), major depression, and anxiety disorder.

Method: Cox models were used with data from a population-based Swedish cohort (N=655,327). Outcomes were drug use disorder, AUD, major depression, and anxiety disorder registrations between ages 17 and 30 from medical, criminal, and pharmacy registries. The authors indexed peer social genetic effects with peers' family genetic risk scores (FGRSs) for the same disorders, which are personalized measures of genetic risk inferred from diagnoses in first- to fifth-degree relatives.

Results: Across disorders, peer FGRSs predicted increased risks of proband registration (hazard ratio range, 1.01-1.59), with stronger effects for drug use disorder and AUD than for major depression and anxiety disorder. Peer social genetic effects were stronger for school classmates than for geographically proximal peers, and for peers from upper secondary school (ages 16-19) versus peers from lower secondary school (ages 7-16). Peer social genetic effects remained significant following statistical control for sociodemographic confounders, whether peers were affected, and peers' FGRS for educational attainment. Peer social genetic effects were more pronounced for probands at higher genetic risk.

Conclusions: The genetic makeup of adolescents' peers has long-reaching consequences on risks for drug use disorder, AUD, major depression, and anxiety disorder. Individuals at high genetic risk are more sensitive to social genetic effects. Alternative hypotheses such as sociodemographic stratification, exposure to affected peers, and genetic predispositions for educational attainment did not explain the risk associated with peer social genetic effects for substance use and psychiatric disorders.

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来源期刊
American Journal of Psychiatry
American Journal of Psychiatry 医学-精神病学
CiteScore
22.30
自引率
2.80%
发文量
157
审稿时长
4-8 weeks
期刊介绍: The American Journal of Psychiatry, dedicated to keeping psychiatry vibrant and relevant, publishes the latest advances in the diagnosis and treatment of mental illness. The journal covers the full spectrum of issues related to mental health diagnoses and treatment, presenting original articles on new developments in diagnosis, treatment, neuroscience, and patient populations.
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