将新兴的纳米酶疗法融入牙科材料，用于治疗各种口腔疾病。

IF 4.6 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2024-11-01 DOI:10.1016/j.dental.2024.07.025

Menghan Zhao , Jin Yang , Jiangyi Liang , Ruixin Shi , Wei Song

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引用次数: 0

摘要

目的：纳米酶材料结合了天然酶和人工催化的优点，已被广泛应用于牙科材料和口腔疾病治疗的新技术中。基于活性氧（ROS）和氧化应激途径在口腔疾病发生和治疗中的作用，本研究对纳米酶及其牙科材料治疗不同口腔疾病的方法和机制进行了全面综述：本综述基于PubMed和Web of Science数据库的文献调查，以及国际同行评审期刊上关于纳米酶治疗口腔疾病和口腔肿瘤的相关研究和出版物的综述：鉴于纳米酶在产生和消除 ROS 方面的独特功能，它们在不同口腔疾病的发生、发展和治疗中发挥着重要作用。论文介绍了纳米酶在牙科材料和口腔疾病治疗中的应用，包括在龋齿、牙髓炎、颌骨骨髓炎、牙周炎、口腔粘膜疾病、颞下颌关节疾病和口腔肿瘤等方面的最新进展。此外，还根据这些疾病的特点总结并提出了未来的治疗方法：本综述将指导生物医学研究人员和口腔临床医生了解纳米酶在口腔疾病治疗中的机制和应用，促进口腔医学材料领域的进一步发展。预计在不久的将来，将会出现更多适合口腔环境、更易于临床使用的治疗剂或封装纳米酶的牙科材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging nanozyme therapy incorporated into dental materials for diverse oral pathologies

Objective

Nanozyme materials combine the advantages of natural enzymes and artificial catalysis, and have been widely applied in new technologies for dental materials and oral disease treatment. Based on the role of reactive oxygen species (ROS) and oxidative stress pathways in the occurrence and therapy of oral diseases, a comprehensive review was conducted on the methods and mechanisms of nanozymes and their dental materials in treating different oral diseases.

Methods

This review is based on literature surveys from PubMed and Web of Science databases, as well as reviews of relevant researches and publications on nanozymes in the therapy of oral diseases and oral tumors in international peer-reviewed journals.

Results

Given the unique function of nanozymes in the generation and elimination of ROS, they play an important role in the occurrence, development, and treatment of different oral diseases. The application of nanozymes in dental materials and oral disease treatment was introduced, including the latest advances in their use for dental caries, pulpitis, jaw osteomyelitis, periodontitis, oral mucosal diseases, temporomandibular joint disorders, and oral tumors. Future approaches were also summarized and proposed based on the characteristics of these diseases.

Significance

This review will guide biomedical researchers and oral clinicians to understand the mechanisms and applications of nanozymes in the therapy of oral diseases, promoting further development in the field of dental materials within the oral medication. It is anticipated that more suitable therapeutic agents or dental materials encapsulating nanozymes, specifically designed for the oral environment and simpler for clinical utilization, will emerge in the forthcoming future.

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.