染色质老化出现了一种模式：AP-1抢尽风头

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2024-08-06 DOI:10.1016/j.cmet.2024.07.015

引用次数: 0

摘要

在衰老过程中，细胞身份的转录程序会受到部分侵蚀，从而降低细胞的适应性和复原力。Patrick 等人1揭示了这一过程的一般机制，即转录因子 AP-1 从细胞特性增强子中逐渐丢失，并通过竞争转移到应激反应元件中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A pattern emerges in chromatin aging: AP-1 steals the show

During aging, transcriptional programs of cell identity are partially eroded, reducing cellular fitness and resilience. Patrick et al.¹ unveil a general mechanism for this process that consists of the progressive loss of transcription factor AP-1 from cell identity enhancers and its relocation by competition to stress-response elements.

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.