染色质老化出现了一种模式：AP-1抢尽风头

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-08-06 DOI:10.1016/j.cmet.2024.07.015

引用次数: 0

摘要

在衰老过程中，细胞身份的转录程序会受到部分侵蚀，从而降低细胞的适应性和复原力。Patrick 等人1揭示了这一过程的一般机制，即转录因子 AP-1 从细胞特性增强子中逐渐丢失，并通过竞争转移到应激反应元件中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A pattern emerges in chromatin aging: AP-1 steals the show

During aging, transcriptional programs of cell identity are partially eroded, reducing cellular fitness and resilience. Patrick et al.¹ unveil a general mechanism for this process that consists of the progressive loss of transcription factor AP-1 from cell identity enhancers and its relocation by competition to stress-response elements.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.