Jun Jie Lim, Sing Wei Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew
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Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha-linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility.</p><p><strong>Results: </strong>In our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054-1.429; adjusted <i>p</i>-value <0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate-to-severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094-2.097; adjusted <i>p</i>-value <0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106-2.256; adjusted <i>p</i>-value <0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD.</p><p><strong>Conclusion: </strong>Overall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 4","pages":"e330"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297457/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of frequent intake of trans fatty acids and saturated fatty acids in diets with increased susceptibility of atopic dermatitis exacerbation in young Chinese adults: A cross-sectional study in Singapore/Malaysia.\",\"authors\":\"Jun Jie Lim, Sing Wei Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew\",\"doi\":\"10.1002/ski2.330\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background & objective: </strong>Numerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of five dietary FAs and AD exacerbations among young Chinese adults from Singapore and Malaysia.</p><p><strong>Methods: </strong>A validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was investigator-administered to 13,561 subjects to collect information on socioeconomic, anthropometric, dietary and lifestyles habits, and personal/family medical histories. Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha-linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility.</p><p><strong>Results: </strong>In our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054-1.429; adjusted <i>p</i>-value <0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate-to-severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094-2.097; adjusted <i>p</i>-value <0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106-2.256; adjusted <i>p</i>-value <0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD.</p><p><strong>Conclusion: </strong>Overall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population.</p>\",\"PeriodicalId\":74804,\"journal\":{\"name\":\"Skin health and disease\",\"volume\":\"4 4\",\"pages\":\"e330\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297457/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Skin health and disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/ski2.330\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Skin health and disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/ski2.330","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景与目的：许多证据表明，脂肪酸（FAs）摄入量高的饮食与特应性皮炎（AD）的发生有关。因此，本研究调查了新加坡和马来西亚年轻华裔成年人中五种膳食脂肪酸的摄入频率与特应性皮炎恶化之间的关系：方法：研究人员对 13,561 名受试者进行了有效的国际儿童哮喘和过敏症研究（ISAAC）问卷调查，以收集有关社会经济、人体测量、饮食和生活习惯以及个人/家庭病史的信息。得出了六种新的膳食指数，以分析膳食中的总脂肪酸、反式脂肪酸、饱和脂肪酸、单不饱和脂肪酸、亚油酸和α-亚麻酸与AD恶化之间的关系。协同因子（SF）分析用于确定膳食脂肪酸之间影响疾病易感性的相互作用：结果：在调整了年龄、性别、体重指数、父母湿疹和生活方式等因素的多变量模型中，估计的总脂肪酸含量高的膳食与AD密切相关（调整后比值比（AOR）：1.227；95% 置信区间（CI）：1.054-1.429；调整后 p 值 p 值 p 值 p 值 结论：总的来说，这些结果突显了膳食中的脂肪酸与AD之间的关系：总之，这些结果突出表明，在亚洲人群中，高反式脂肪酸和饱和脂肪酸膳食与注意力缺失症加重之间存在关联。
Association of frequent intake of trans fatty acids and saturated fatty acids in diets with increased susceptibility of atopic dermatitis exacerbation in young Chinese adults: A cross-sectional study in Singapore/Malaysia.
Background & objective: Numerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of five dietary FAs and AD exacerbations among young Chinese adults from Singapore and Malaysia.
Methods: A validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was investigator-administered to 13,561 subjects to collect information on socioeconomic, anthropometric, dietary and lifestyles habits, and personal/family medical histories. Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha-linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility.
Results: In our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054-1.429; adjusted p-value <0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate-to-severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094-2.097; adjusted p-value <0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106-2.256; adjusted p-value <0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD.
Conclusion: Overall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population.
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