辐射所致肺损伤的致病机制和最新治疗方法：综述。

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2024-08-03 DOI:10.1016/j.critrevonc.2024.104461

Sitong Chang , Jincai Lv , Xuanzhong Wang , Jing Su , Chenbin Bian , Zhuangzhuang Zheng , Huiyuan Yu , Jindian Bao , Ying Xin , Xin Jiang

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引用次数: 0

摘要

用电离辐射治疗胸部肿瘤会导致辐射诱导的肺损伤（RILI），包括放射性肺炎和辐射诱导的肺纤维化。预防 RILI 对控制肿瘤生长和改善生活质量至关重要。然而，传统 RILI 治疗方法的严重不良反应仍是一大障碍，因此有必要开发既安全又有效的新型治疗方案。本综述总结了 RILI 的分子机制，并探讨了新型治疗方案，包括天然化合物、基因疗法、纳米材料和间充质干细胞。这些最新的实验方法显示了在临床实践中有效预防和治疗 RILI 的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pathogenic mechanisms and latest therapeutic approaches for radiation-induced lung injury: A narrative review

The treatment of thoracic tumors with ionizing radiation can cause radiation-induced lung injury (RILI), which includes radiation pneumonitis and radiation-induced pulmonary fibrosis. Preventing RILI is crucial for controlling tumor growth and improving quality of life. However, the serious adverse effects of traditional RILI treatment methods remain a major obstacle, necessitating the development of novel treatment options that are both safe and effective. This review summarizes the molecular mechanisms of RILI and explores novel treatment options, including natural compounds, gene therapy, nanomaterials, and mesenchymal stem cells. These recent experimental approaches show potential as effective prevention and treatment options for RILI in clinical practice.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.