用于急性缺血性脑卒中再灌注的新兴辅助溶栓疗法

IF 7.8 1区医学 Q1 CLINICAL NEUROLOGY

Stroke Pub Date : 2024-08-06 DOI:10.1161/STROKEAHA.124.045755

Vignan Yogendrakumar, Sarah Vandelanotte, Eva A Mistry, Michael D Hill, Shelagh B Coutts, Raul G Nogueira, Thanh N Nguyen, Robert L Medcalf, Joseph P Broderick, Simon F De Meyer, Bruce C V Campbell

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引用次数: 0

摘要

治疗急性缺血性脑卒中的溶栓疗法已广泛使用，但只有 10%至 30% 的病例能在足够早的时间内实现再通畅，从而起到治疗作用。新型疗法可以在不显著增加伤害风险的情况下提高血栓清除效果，从而弥补治疗效果上的巨大差距。本报告将重点介绍急性缺血性脑卒中再灌注新兴辅助疗法的现状。我们将重点关注以下方面的新疗法：(1) 针对构成中风血栓的不同成分；(2) 增强内源性纤维蛋白溶解系统；(3) 减少停滞血流；(4) 改善远端血栓再通和血管内血栓切除术后血栓再通。

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Emerging Adjuvant Thrombolytic Therapies for Acute Ischemic Stroke Reperfusion.

Thrombolytic therapies for acute ischemic stroke are widely available but only result in recanalization early enough, to be therapeutically useful, in 10% to 30% of cases. This large gap in treatment effectiveness could be filled by novel therapies that can increase the effectiveness of thrombus clearance without significantly increasing the risk of harm. This focused update will describe the current state of emerging adjuvant treatments for acute ischemic stroke reperfusion. We focus on new treatments that are designed to (1) target different components that make up a stroke thrombus, (2) enhance endogenous fibrinolytic systems, (3) reduce stagnant blood flow, and (4) improve recanalization of distal thrombi and postendovascular thrombectomy.

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来源期刊

Stroke 医学-临床神经学

CiteScore

13.40

自引率

6.00%

发文量

2021

审稿时长

3 months

期刊介绍： Stroke is a monthly publication that collates reports of clinical and basic investigation of any aspect of the cerebral circulation and its diseases. The publication covers a wide range of disciplines including anesthesiology, critical care medicine, epidemiology, internal medicine, neurology, neuro-ophthalmology, neuropathology, neuropsychology, neurosurgery, nuclear medicine, nursing, radiology, rehabilitation, speech pathology, vascular physiology, and vascular surgery. The audience of Stroke includes neurologists, basic scientists, cardiologists, vascular surgeons, internists, interventionalists, neurosurgeons, nurses, and physiatrists. Stroke is indexed in Biological Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts, CINAHL, Current Contents, Embase, MEDLINE, and Science Citation Index Expanded.