中性粒细胞胞外陷阱:中药和天然产品治疗类风湿性关节炎的潜在靶点。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Phytotherapy Research Pub Date : 2024-11-01 Epub Date: 2024-08-06 DOI:10.1002/ptr.8311
Yuan Liu, Yuan Qu, Chuanguo Liu, Di Zhang, Bing Xu, Yakun Wan, Ping Jiang
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种慢性全身性自身免疫性疾病。滑膜上中性粒细胞胞外捕获物(NET)的异常形成会导致许多炎症细胞因子的释放,包括 IL-1β、IL-6 和 TNF-α。NET携带的弹性蛋白酶、组蛋白H3和髓过氧化物酶会损伤关节软组织,加剧RA的恶化。NET 形成的平衡协调了促炎和抗炎作用,在 RA 的发展中起着关键作用。因此,如果将 NET 作为效应靶点,就可以开发出副作用较小的高靶向药物,在不损害宿主免疫系统的情况下治疗 RA。目前,越来越多的研究表明,中药和天然产物可以通过多种途径调节NETs的形成,从而对抗RA,这在治疗RA方面显示出巨大的潜力,临床应用前景广阔。本文综述了对NET形成认识的最新生物学进展、NET在RA中的作用机制,以及中药和天然产物调节NET形成的潜在靶点或相关途径。该综述为中药和天然产物作为天然佐剂用于治疗RA提供了相关依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neutrophil extracellular traps: Potential targets for the treatment of rheumatoid arthritis with traditional Chinese medicine and natural products.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Abnormal formation of neutrophil extracellular traps (NETs) at the synovial membrane leads to the release of many inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Elastase, histone H3, and myeloperoxidase, which are carried by NETs, damage the soft tissues of the joints and aggravate the progression of RA. The balance of NET formation coordinates the pro-inflammatory and anti-inflammatory effects and plays a key role in the development of RA. Therefore, when NETs are used as effector targets, highly targeted drugs with fewer side effects can be developed to treat RA without damaging the host immune system. Currently, an increasing number of studies have shown that traditional Chinese medicines and natural products can regulate the formation of NETs through multiple pathways to counteract RA, which shows great potential for the treatment of RA and has a promising future for clinical application. In this article, we review the latest biological progress in understanding NET formation, the mechanism of NETs in RA, and the potential targets or pathways related to the modulation of NET formation by Chinese medicines and natural products. This review provides a relevant basis for the use of Chinese medicines and natural products as natural adjuvants in the treatment of RA.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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