揭示 LncRNA 在胃癌发病机制中的影响:侧重于信号通路相互作用的全面综述。

IF 2.8 4区 医学 Q2 ONCOLOGY
Hanan Elimam, Sherif S Abdel Mageed, Abdulrahman Hatawsh, Rewan Moussa, Abdullah F Radwan, Nourhan Elfar, Nora A A Alhamshry, Mai A Abd-Elmawla, Osama A Mohammed, Mohamed Bakr Zaki, Ahmed S Doghish
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引用次数: 0

摘要

胃癌(GC)是世界上最常见、最致命的恶性肿瘤之一。尽管我们对胃癌的分子机制有了越来越多的了解,但仍需要更多的生物标志物来进行更深入的检查、重点预后和治疗。GC 是长非编码 RNA(或称 lncRNA)之一,已成为癌症病理生理学的关键调控因子。这篇综合综述重点探讨了长非编码 RNA(lncRNA)在 GC 发展过程中的各种功能及其与细胞内重要信号通路的相互作用。LncRNAs 影响与 GC 相关的致癌信号级联,包括表皮生长因子受体、PI3K/AKT/mTOR、p53、Wnt/β-catenin、JAK/STAT、刺猬、NF-κB 和缺氧诱导因子的通路。长非编码 RNA(lncRNA)表达失调与癌症的多种特征有关,如生长延长、凋亡抵抗、侵袭和转移增强、血管生成和治疗抵抗。例如,HOTAIR、MALAT1 和 H19 等 lncRNA 可通过改变这些途径促进 GC 的发展。除了它们的主要作用外,GC lncRNA 还具有作为诊断和预后生物标志物的潜力。本综述讨论了 CRISPR/Cas9 基因组修饰方法、反义寡核苷酸、小分子和 RNA 干扰作为调节长非编码 RNA(lncRNA)表达的潜在治疗方法。本综述深入探讨了 lncRNA 在大多数胃部恶性肿瘤的发病过程中发挥的复杂功能。该综述强调了lncRNA的致癌作用、在重要信号级联中的调控作用以及作为生物标记物和治疗靶点的实际科学用途,为未来基于lncRNA的胃癌全过程转化研究奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay.

Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay.

Gastric cancers (GCs) are among the most common and fatal malignancies in the world. Despite our increasing understanding of the molecular mechanisms underlying GC, further biomarkers are still needed for more in-depth examination, focused prognosis, and treatment. GC is one among the long non-coding RNAs, or lncRNAs, that have emerged as key regulators of the pathophysiology of cancer. This comprehensive review focuses on the diverse functions of long noncoding RNAs (lncRNAs) in the development of GC and their interactions with important intracellular signaling pathways. LncRNAs affect GC-related carcinogenic signaling cascades including pathways for EGFR, PI3K/AKT/mTOR, p53, Wnt/β-catenin, JAK/STAT, Hedgehog, NF-κB, and hypoxia-inducible factor. Dysregulated long non-coding RNA (lncRNA) expression has been associated with multiple characteristics of cancer, such as extended growth, apoptosis resistance, enhanced invasion and metastasis, angiogenesis, and therapy resistance. For instance, lncRNAs such as HOTAIR, MALAT1, and H19 promote the development of GC via altering these pathways. Beyond their main roles, GC lncRNAs exhibit potential as diagnostic and prognostic biomarkers. The overview discusses CRISPR/Cas9 genome-modifying methods, antisense oligonucleotides, small molecules, and RNA interference as potential therapeutic approaches to regulate the expression of long noncoding RNAs (lncRNAs). An in-depth discussion of the intricate functions that lncRNAs play in the development of the majority of stomach malignancies is provided in this review. It provides the groundwork for future translational research in lncRNA-based whole processes toward GC by highlighting their carcinogenic effects, regulatory roles in significant signaling cascades, and practical scientific uses as biomarkers and therapeutic targets.

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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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