非甾体抗炎药对术后谵妄的影响:一项荟萃分析。

IF 4.2 4区 医学 Q1 ANESTHESIOLOGY
Korean Journal of Anesthesiology Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI:10.4097/kja.24325
Su Yeon Kim, Hyo-Seok Na, Jung-Hee Ryu, Hyun-Jung Shin
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引用次数: 0

摘要

背景:神经炎症被认为是导致术后谵妄的潜在机制。本研究旨在调查非甾体抗炎药(NSAID)的使用对术后谵妄的影响:我们在电子数据库(包括 PubMed、EMBASE、CENTRAL 和 Web of Science)中进行了文献检索,以确定符合条件的随机对照研究。主要结果是术后谵妄的发生率,次要结果包括疼痛评分和术后 24 小时阿片类药物的使用量。我们通过计算几率比(OR)或平均差(MD)以及 95% CI(视情况而定)来估计效应大小:在对涉及 1238 名参与者的 8 项研究进行的分析中,非甾体抗炎药组和对照组的术后谵妄发生率分别为 11% 和 19%,非甾体抗炎药组的发生率显著降低(OR,0.54;95% CI,0.38 至 0.76;P = 0.0001;I2 = 0%)。使用非甾体抗炎药对减轻术后疼痛有显著效果(MD,-0.75;95% CI,-1.37 至 -0.13;P = 0.0172;I2 = 88%)。非甾体抗炎药组的术后阿片类药物用量显著降低(MD,-2.88;95% CI,-3.54 至 -2.22;P = 0.000;I2 = 0%):结论:服用非甾体抗炎药可降低术后谵妄的发生率、疼痛的严重程度和阿片类药物的使用剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of non-steroidal anti-inflammatory drugs on postoperative delirium: a meta-analysis.

Background: Neuroinflammation is postulated as a potential mechanism underlying postoperative delirium. This study aimed to investigate the impact of non-steroidal anti-inflammatory drug (NSAID) use on postoperative delirium.

Methods: We conducted a literature search in electronic databases, including PubMed, EMBASE, CENTRAL, and Web of Science, to identify eligible randomized controlled studies. The primary outcome was the incidence of postoperative delirium, and the secondary outcomes included pain scores and the amounts of opioid used at 24 h postoperatively. We estimated the effect size through calculating the odds ratios (ORs) or mean differences (MDs) with 95% CIs, as appropriate.

Results: In the analysis of eight studies involving 1,238 participants, the incidence of postoperative delirium was 11% and 19% in the NSAID and control groups, respectively, with a significant reduction in the NSAID group (OR: 0.54, 95% CI [0.38, 0.7], P = 0.0001, I2 = 0%). NSAID use had a significant effect on postoperative pain reduction (MD: -0.75, 95% CI [-1.37, -0.13], P = 0.0172, I2 = 88%). Significant lower postoperative opioid consumption was observed in the NSAID group (MD: -2.88, 95% CI [-3.54, -2.22], P = 0.0000; I2 = 0%).

Conclusions: NSAID administration reduced the incidence of postoperative delirium, severity of pain, and opioid dose used.

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来源期刊
CiteScore
6.20
自引率
6.90%
发文量
84
审稿时长
16 weeks
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