生物硫酸镁和精氨酸硅酸盐复合物对高脂饮食大鼠代谢功能障碍、抗氧化活性、炎症和神经调节的影响

IF 3.2 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Kazim Sahin, Emre Sahin, Cemal Orhan, Besir Er, Bayram Akoglan, Ibrahim Hanifi Ozercan, Nurhan Sahin, James R Komorowski
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引用次数: 0

摘要

生物素和精氨酸在脂质代谢中起着至关重要的作用,可为肥胖症提供有前景的干预措施。本研究考察了生物素镁(MgB)和肌醇稳定的精氨酸硅酸盐复合物(ASI)对高脂饮食大鼠肥胖相关的氧化失衡、炎症、脂质代谢和神经调节的综合影响。40 只大鼠被分为 5 组:(a)对照组:喂食含 12% 脂肪能量的标准饮食;(b)高脂饮食组:喂食含 42% 脂肪能量的高脂饮食;(c)高脂饮食 + MgB 组:喂食高脂饮食并给予 0.31毫克/千克体重(BW)的 MgB;(d)HFD + ASI:喂食 HFD 的大鼠并给予 12.91 毫克/千克体重的 ASI);以及(e)HFD + MgB + ASI:喂食 HFD 的大鼠并给予 0.31 毫克/千克体重的 MgB 和 12.91 毫克/千克体重的 ASI)。联合施用 MgB 和 ASI 可降低血清胆固醇、游离脂肪酸 (FFA) 和丙二醛 (MDA) 的水平,以及肝脏炎症细胞因子、固醇调节因子结合蛋白 1-c (SREBP-1c) 和 3- 羟基-3-甲基戊二酰-CoA 还原酶 (HMGR) 蛋白的水平(P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The impact of magnesium biotinate and arginine silicate complexes on metabolic dysfunctions, antioxidant activity, inflammation, and neuromodulation in high-fat diet-fed rats.

The impact of magnesium biotinate and arginine silicate complexes on metabolic dysfunctions, antioxidant activity, inflammation, and neuromodulation in high-fat diet-fed rats.

Biotin and arginine play crucial roles in lipid metabolism and may offer promising interventions against obesity. This study examined the combined effect of magnesium biotinate (MgB) and inositol-stabilized arginine silicate complex (ASI) on obesity-related oxidative imbalance, inflammation, lipid metabolism and neuromodulation in rats on a high-fat diet (HFD). Forty rats were divided into five groups: (a) control: rats were fed a standard diet containing 12% of energy from fat; (b) HFD: rats were fed the HFD with 42% of energy from fat; (c) HFD + MgB: rats were fed the HFD and given 0.31 mg/kg body weight (BW) MgB, (d) HFD + ASI: rats were fed the HFD and were given 12.91 mg/kg BW ASI), and (e) HFD + MgB + ASI: rats were fed the HFD and given 0.31 mg/kg BW MgB and 12.91 mg/kg BW ASI). The combined administration of MgB and ASI reduced the levels of serum cholesterol, free fatty acid (FFA), and malondialdehyde (MDA), as well as liver inflammatory cytokines, sterol regulatory element-binding protein 1-c (SREBP-1c), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) proteins (P < 0.001) compared to HFD rats without supplementation. Moreover, this combination increased the activities of antioxidant enzymes (P < 0.05) and boosted the brain-derived neurotrophic factor (BDNF), serotonin, dopamine (P < 0.001), as well as liver insulin receptor substrate 1 (IRS-1) and peroxisome proliferator-activated receptor gamma (PPAR-γ) (P < 0.001). These findings suggest that combining MgB and ASI could deter liver fat accumulation and enhance lipid metabolism in HFD-fed rats by modulating various metabolic pathways and neuromodulators related to energy metabolism. This combination demonstrates potential in addressing obesity and its related metabolic dysfunctions.

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来源期刊
Clinical and Experimental Medicine
Clinical and Experimental Medicine 医学-医学:研究与实验
CiteScore
4.80
自引率
2.20%
发文量
159
审稿时长
2.5 months
期刊介绍: Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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