高分辨率光学相干断层扫描能否为眼表病变提供光学活检?

IF 3.3 4区 医学 Q1 OPHTHALMOLOGY
William R Herskowitz, Sofia De Arrigunaga, Jason A Greenfield, Noah K Cohen, Anat Galor, Carol L Karp
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引用次数: 0

摘要

高分辨率光学相干断层扫描(HR-OCT)改变了眼表病变的诊断和管理。HR-OCT 提供角膜和结膜的详细横截面图像,可用于识别各种良性和恶性眼表病变的特征,帮助诊断和指导治疗。在眼科临床中,HR-OCT 以类似 "光学活检 "的无创方式提供病变的形态学图像。一些病变的 HR-OCT 特征在文献中已有详细描述,包括眼表面鳞状细胞瘤、乳头状瘤、黑色素瘤、原发性获得性黑变病、肤色相关性黑变病、痣、翼状胬肉、胬肉、淋巴瘤和淀粉样变性。HR-OCT 可用于区分具有相似临床特征的病变、在同一眼表同时存在的病变以及表现不典型的病变,如色素性眼表鳞状上皮瘤或黑色素瘤。HR-OCT 的应用改变了眼表病变的治疗方法,使临床医生有能力监测肿瘤对局部化疗的反应,跟踪以前切除的病变是否复发,以及在术中绘制肿瘤边界。虽然 HR-OCT 还存在一些局限性,包括对较厚或较深病灶的成像,但它已成为眼部肿瘤专家治疗眼表病变的重要工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can high-resolution optical coherence tomography provide an optical biopsy for ocular surface lesions?

High-resolution optical coherence tomography (HR-OCT) has transformed the diagnosis and management of ocular surface lesions. Providing a detailed cross-sectional view of the cornea and conjunctiva, HR-OCT can be used to identify characteristic features of various benign and malignant ocular surface lesions, aiding in their diagnosis and guiding treatment. When incorporated into an ophthalmology clinic, HR-OCT provides morphological images of lesions in a noninvasive means, akin to an "optical biopsy". The characteristic HR-OCT features of several lesions have been well described in the literature, including for ocular surface squamous neoplasia, papilloma, melanoma, primary acquired melanosis, complexion associated melanosis, nevus, pterygium, pinguecula, lymphoma, and amyloidosis. HR-OCT can be used to differentiate between lesions with similar clinical features, lesions that co-exist on the same ocular surface, and atypically presenting lesions, such as pigmented ocular surface squamous neoplasia or amelanotic melanoma. The management of ocular surface lesions has been transformed by the implementation of HR-OCT, providing clinicians with the ability to monitor tumor response to topical chemotherapies, follow previously excised lesions for recurrence, and map out tumor borders intraoperatively. While there are some limitations to HR-OCT, including imaging of thick or deep lesions, it has become an essential tool for ocular oncologists in the management of ocular surface lesions.

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来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
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