患有抑郁症的青少年的睡眠质量以及皮质醇和α-淀粉酶的觉醒反应。

IF 3.9 3区 医学 Q1 PSYCHIATRY
BJPsych Open Pub Date : 2024-08-06 DOI:10.1192/bjo.2024.730
Rebekka Krempel, Irina Jarvers, Angelika Ecker, Daniel Schleicher, Romuald Brunner, Stephanie Kandsperger
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引用次数: 0

摘要

背景:青少年抑郁障碍影响生活的方方面面,并造成巨大的疾病负担。睡眠经常受到抑郁症的影响,而睡眠对于面对成长过程中的挑战至关重要。目的:研究青少年抑郁障碍与主观睡眠质量、客观睡眠质量以及睡醒后皮质醇和α-淀粉酶变化的关系:我们比较了35名患有抑郁障碍的青少年和29名健康对照组青少年连续7天的主观睡眠质量(通过每日问卷调查)和客观睡眠质量(通过动图测量)。此外,研究人员还收集了3天的唾液样本,以检测醒后皮质醇和α-淀粉酶的变化规律:结果:在皮质醇或α-淀粉酶觉醒反应方面,抑郁障碍参与者与健康对照组之间没有发现明显差异。我们发现,与对照组相比,抑郁症组的主观睡眠质量严重下降(Z = -5.19,P < 0.001,d = 1.80),动觉仪测量的睡眠开始潜伏期延长(Z = -2.42,P = 0.015,d = 0.64)。主观睡眠质量的下降与客观睡眠测量结果部分相关(睡眠开始潜伏期:r = -0.270,P = 0.004;睡眠效率:r = 0.215,P = 0.017):结论:睡眠开始潜伏期似乎会加重抑郁症状,并对睡眠质量的感知有重要影响。患有抑郁症的青少年应养成良好的睡眠卫生习惯,避免从事可能妨碍入睡的活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sleep quality and the cortisol and alpha-amylase awakening responses in adolescents with depressive disorders.

Background: Depressive disorders in adolescents affect all aspects of life and impose a very large burden of disease. Sleep is frequently affected by depression and is crucial for facing challenges during development. One of the postulated reasons for depression-induced sleep disruption is dysregulation of the physiological stress system.

Aims: To investigate the links of adolescent depressive disorders with subjective sleep quality, objective sleep quality, and the course of cortisol and alpha-amylase after awakening.

Method: We compared subjective sleep quality (via daily questionnaires) and objective sleep quality (via actigraphy measurement) of 35 adolescents with depressive disorders and 29 healthy controls over 7 consecutive days. In addition, saliva samples were collected on 3 days to examine cortisol and alpha-amylase patterns after awakening.

Results: No significant differences in cortisol or alpha-amylase awakening responses were observed between participants with depressive disorders and healthy controls. We found severe reductions in subjective sleep quality in the depression group (Z = -5.19, P < 0.001, d = 1.80) and a prolonged actigraphy-measured sleep onset latency (Z = -2.42, P = 0.015, d = 0.64) compared with controls. Reductions in subjective sleep quality were partially correlated with objective sleep measures (sleep onset latency: r = -0.270, P = 0.004, sleep efficiency: r = 0.215, P = 0.017).

Conclusions: Sleep onset latency seems to aggravate depressive symptoms and to have an important role in perception of sleep quality. Adolescents with depressive disorders should be supported regarding the establishment of good sleep hygiene and avoiding activities that may impede falling asleep.

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来源期刊
BJPsych Open
BJPsych Open Medicine-Psychiatry and Mental Health
CiteScore
6.30
自引率
3.70%
发文量
610
审稿时长
16 weeks
期刊介绍: Announcing the launch of BJPsych Open, an exciting new open access online journal for the publication of all methodologically sound research in all fields of psychiatry and disciplines related to mental health. BJPsych Open will maintain the highest scientific, peer review, and ethical standards of the BJPsych, ensure rapid publication for authors whilst sharing research with no cost to the reader in the spirit of maximising dissemination and public engagement. Cascade submission from BJPsych to BJPsych Open is a new option for authors whose first priority is rapid online publication with the prestigious BJPsych brand. Authors will also retain copyright to their works under a creative commons license.
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