巴西孕产妇暴露于环境温度与出生缺陷:一项针对 1100 多万新生儿的全国性病例对照研究。

IF 3 3区 地球科学 Q2 BIOPHYSICS
Weeberb J. Requia, Stefania Papatheodorou
{"title":"巴西孕产妇暴露于环境温度与出生缺陷:一项针对 1100 多万新生儿的全国性病例对照研究。","authors":"Weeberb J. Requia,&nbsp;Stefania Papatheodorou","doi":"10.1007/s00484-024-02746-x","DOIUrl":null,"url":null,"abstract":"<div><p>Maternal exposure to extreme ambient temperature during pregnancy has been proposed as a potential risk factor for birth defects. Comprehensive investigations on this association remain limited, particularly in low- and middle-income countries. This study aims to examine the association between ambient temperature exposure during pregnancy and the risk of birth defects in Brazil, contributing to the broader understanding of environmental influences on birth outcomes. Using a large dataset of over 11 million live birth records, we analyzed 12 categories of birth defects, encompassing a time frame from 2001 to 2018. Ambient temperature data were assigned at the municipality level. For the exposure assessment, we considered two biologically driven pregnancy stages by dividing the gestational period into two specific windows: the first trimester (from week 1 to week 12) and the second trimester (from week 13 to week 28). We employed a two-stage case–control design. In the first stage, we applied a conditional logistic regression model to estimate the odds ratio (OR) for specific birth defects and each of the five Brazilian regions (North, Northeast, Midwest, Southeast, and South). The model was adjusted for potential confounding variables, including PM<sub>2.5</sub>, relative humidity, and socioeconomic status. Temporal trends were addressed using time-stratified sampling. In the second stage, we used mixed-effects meta-analysis to pool region-specific estimates. Our analysis revealed a significant association between maternal exposure to higher ambient temperatures during the first trimester and an increased risk of specific birth defect categories, including those affecting the genital organs (OR = 1.08, 95% CI: 1.02; 1.14), digestive system (OR = 1.12, 95% CI: 1.06; 1.19); circulatory system (OR = 1.08, 95% CI: 1.01; 1.17); eyes, ears, face, and neck (OR = 1.08, 95% CI: 1.02; 1.15); benign neoplasms tumors (OR = 1.17, 95% CI: 1.03; 1.32), musculoskeletal system (OR = 1.03, 95% CI: 1.01; 1.05); and other congenital anomalies (OR = 1.22, 95% CI: 1.15; 1.29). The associations with respiratory system, nervous system, and chromosomal anomalies were null. These findings have significant implications for public health policies aimed at mitigating the impact of environmental factors on birth outcomes, both in Brazil and globally.</p></div>","PeriodicalId":588,"journal":{"name":"International Journal of Biometeorology","volume":"68 11","pages":"2297 - 2305"},"PeriodicalIF":3.0000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Maternal exposure to ambient temperature and birth defects in Brazil: a nationwide case–control study of over 11 million newborns\",\"authors\":\"Weeberb J. Requia,&nbsp;Stefania Papatheodorou\",\"doi\":\"10.1007/s00484-024-02746-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Maternal exposure to extreme ambient temperature during pregnancy has been proposed as a potential risk factor for birth defects. Comprehensive investigations on this association remain limited, particularly in low- and middle-income countries. This study aims to examine the association between ambient temperature exposure during pregnancy and the risk of birth defects in Brazil, contributing to the broader understanding of environmental influences on birth outcomes. Using a large dataset of over 11 million live birth records, we analyzed 12 categories of birth defects, encompassing a time frame from 2001 to 2018. Ambient temperature data were assigned at the municipality level. For the exposure assessment, we considered two biologically driven pregnancy stages by dividing the gestational period into two specific windows: the first trimester (from week 1 to week 12) and the second trimester (from week 13 to week 28). We employed a two-stage case–control design. In the first stage, we applied a conditional logistic regression model to estimate the odds ratio (OR) for specific birth defects and each of the five Brazilian regions (North, Northeast, Midwest, Southeast, and South). The model was adjusted for potential confounding variables, including PM<sub>2.5</sub>, relative humidity, and socioeconomic status. Temporal trends were addressed using time-stratified sampling. In the second stage, we used mixed-effects meta-analysis to pool region-specific estimates. Our analysis revealed a significant association between maternal exposure to higher ambient temperatures during the first trimester and an increased risk of specific birth defect categories, including those affecting the genital organs (OR = 1.08, 95% CI: 1.02; 1.14), digestive system (OR = 1.12, 95% CI: 1.06; 1.19); circulatory system (OR = 1.08, 95% CI: 1.01; 1.17); eyes, ears, face, and neck (OR = 1.08, 95% CI: 1.02; 1.15); benign neoplasms tumors (OR = 1.17, 95% CI: 1.03; 1.32), musculoskeletal system (OR = 1.03, 95% CI: 1.01; 1.05); and other congenital anomalies (OR = 1.22, 95% CI: 1.15; 1.29). The associations with respiratory system, nervous system, and chromosomal anomalies were null. These findings have significant implications for public health policies aimed at mitigating the impact of environmental factors on birth outcomes, both in Brazil and globally.</p></div>\",\"PeriodicalId\":588,\"journal\":{\"name\":\"International Journal of Biometeorology\",\"volume\":\"68 11\",\"pages\":\"2297 - 2305\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Biometeorology\",\"FirstCategoryId\":\"89\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00484-024-02746-x\",\"RegionNum\":3,\"RegionCategory\":\"地球科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biometeorology","FirstCategoryId":"89","ListUrlMain":"https://link.springer.com/article/10.1007/s00484-024-02746-x","RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0

摘要

孕产妇在怀孕期间暴露于极端环境温度被认为是导致出生缺陷的潜在风险因素。有关这种关联的全面调查仍然有限,尤其是在中低收入国家。本研究旨在探讨巴西孕妇在怀孕期间暴露于环境温度与出生缺陷风险之间的关系,从而帮助人们更广泛地了解环境对出生结果的影响。我们利用一个包含 1100 多万条活产记录的大型数据集,分析了 12 类出生缺陷,时间跨度为 2001 年至 2018 年。环境温度数据按城市级别分配。对于暴露评估,我们考虑了两个生物学驱动的妊娠阶段,将妊娠期分为两个特定窗口:妊娠前三个月(从第 1 周到第 12 周)和妊娠后三个月(从第 13 周到第 28 周)。我们采用了两阶段病例对照设计。在第一阶段,我们采用条件逻辑回归模型来估算特定出生缺陷与巴西五个地区(北部、东北部、中西部、东南部和南部)的几率比(OR)。该模型对潜在的混杂变量(包括 PM2.5、相对湿度和社会经济状况)进行了调整。使用时间分层抽样法解决了时间趋势问题。在第二阶段,我们使用混合效应荟萃分析法汇集了特定地区的估计值。我们的分析表明,孕产妇在怀孕头三个月暴露于较高的环境温度与特定出生缺陷类别的风险增加之间存在明显关联,包括影响生殖器官(OR = 1.08,95% CI:1.02; 1.14)、消化系统(OR = 1.12,95% CI:1.06; 1.19);循环系统(OR = 1.08,95% CI:1.01; 1.17);眼、耳、面部和颈部(OR = 1.08,95% CI:1.02; 1.15);良性肿瘤(OR = 1.17,95% CI:1.03;1.32)、肌肉骨骼系统(OR = 1.03,95% CI:1.01;1.05)和其他先天性异常(OR = 1.22,95% CI:1.15;1.29)。与呼吸系统、神经系统和染色体异常的相关性为零。这些发现对巴西和全球旨在减轻环境因素对出生结果影响的公共卫生政策具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Maternal exposure to ambient temperature and birth defects in Brazil: a nationwide case–control study of over 11 million newborns

Maternal exposure to ambient temperature and birth defects in Brazil: a nationwide case–control study of over 11 million newborns

Maternal exposure to extreme ambient temperature during pregnancy has been proposed as a potential risk factor for birth defects. Comprehensive investigations on this association remain limited, particularly in low- and middle-income countries. This study aims to examine the association between ambient temperature exposure during pregnancy and the risk of birth defects in Brazil, contributing to the broader understanding of environmental influences on birth outcomes. Using a large dataset of over 11 million live birth records, we analyzed 12 categories of birth defects, encompassing a time frame from 2001 to 2018. Ambient temperature data were assigned at the municipality level. For the exposure assessment, we considered two biologically driven pregnancy stages by dividing the gestational period into two specific windows: the first trimester (from week 1 to week 12) and the second trimester (from week 13 to week 28). We employed a two-stage case–control design. In the first stage, we applied a conditional logistic regression model to estimate the odds ratio (OR) for specific birth defects and each of the five Brazilian regions (North, Northeast, Midwest, Southeast, and South). The model was adjusted for potential confounding variables, including PM2.5, relative humidity, and socioeconomic status. Temporal trends were addressed using time-stratified sampling. In the second stage, we used mixed-effects meta-analysis to pool region-specific estimates. Our analysis revealed a significant association between maternal exposure to higher ambient temperatures during the first trimester and an increased risk of specific birth defect categories, including those affecting the genital organs (OR = 1.08, 95% CI: 1.02; 1.14), digestive system (OR = 1.12, 95% CI: 1.06; 1.19); circulatory system (OR = 1.08, 95% CI: 1.01; 1.17); eyes, ears, face, and neck (OR = 1.08, 95% CI: 1.02; 1.15); benign neoplasms tumors (OR = 1.17, 95% CI: 1.03; 1.32), musculoskeletal system (OR = 1.03, 95% CI: 1.01; 1.05); and other congenital anomalies (OR = 1.22, 95% CI: 1.15; 1.29). The associations with respiratory system, nervous system, and chromosomal anomalies were null. These findings have significant implications for public health policies aimed at mitigating the impact of environmental factors on birth outcomes, both in Brazil and globally.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.40
自引率
9.40%
发文量
183
审稿时长
1 months
期刊介绍: The Journal publishes original research papers, review articles and short communications on studies examining the interactions between living organisms and factors of the natural and artificial atmospheric environment. Living organisms extend from single cell organisms, to plants and animals, including humans. The atmospheric environment includes climate and weather, electromagnetic radiation, and chemical and biological pollutants. The journal embraces basic and applied research and practical aspects such as living conditions, agriculture, forestry, and health. The journal is published for the International Society of Biometeorology, and most membership categories include a subscription to the Journal.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信