用于心血管工程的制氧生物材料:揭开未来发现的神秘面纱。

IF 6.5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Masoud Mozafari , Mohammad E. Barbati
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引用次数: 0

摘要

氧气生成生物材料正在成为改变心血管工程的突破性解决方案。这些生物材料在各种生物医学应用中产生并释放氧气,标志着医疗保健领域的一个新领域。大多数心血管治疗都面临着一个重大挑战,即确保持续的氧气供应,以培育工程组织甚至植入装置。依靠被动氧气扩散的传统方法往往达不到要求,从而阻碍了心血管组织的功能发育。结合了过氧化钙等制剂的氧气生成生物材料可为周围细胞提供可控的氧气源。这种创新技术有可能提高细胞活力、刺激生长并促进对组织健康至关重要的新陈代谢活动。其应用包括修复心脏和血管组织、疾病建模、药物测试和个性化医疗,有望实现量身定制的治疗方法。需要考虑的挑战包括材料毒性和氧气释放控制。随着研究的深入,这些创新生物材料在临床转化中的应用可能会重塑心血管医疗保健,彻底改变心脏病治疗的患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxygen-generating biomaterials for cardiovascular engineering: unveiling future discoveries

Oxygen-generating biomaterials are emerging as a groundbreaking solution for transforming cardiovascular engineering. These biomaterials generate and release oxygen within various biomedical applications, marking a new frontier in healthcare. Most cardiovascular treatments face a significant challenge, ensuring a consistent oxygen supply to nurture engineered tissues or even implanted devices. Traditional methods relying on passive oxygen diffusion often fall short, hindering functional cardiovascular tissue development. Oxygen-generating biomaterials, incorporating agents like calcium peroxide, provide a controlled oxygen source to the surrounding cells. This innovation potentially enhances cell viability, stimulates growth and boosts metabolic activity crucial for tissue health. Applications include repairing cardiac and vascular tissues, disease modeling, drug testing and personalized medicine, promising tailored treatments. Challenges like material toxicity and oxygen release control need consideration. As research progresses, the use of these innovative biomaterials in clinical translation could reshape cardiovascular healthcare, revolutionizing patient outcomes in heart disease treatment.

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来源期刊
Drug Discovery Today
Drug Discovery Today 医学-药学
CiteScore
14.80
自引率
2.70%
发文量
293
审稿时长
6 months
期刊介绍: Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.
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