转移性胰腺癌和肝脏

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI:10.1038/s41575-024-00972-7

Eleni Kotsiliti

引用次数: 0

摘要

最近发表在《自然医学》（Nature Medicine）上的一项研究描述了利用肝脏活检样本预测早期胰腺癌（PaC）转移结果的转移前特征多参数图谱。研究人员在胰腺切除术中获得了局部胰腺癌患者（49人）和无癌性病变患者（19人）的肝脏活检样本，并结合成像技术、代谢组学、组织和单细胞转录组学对肝脏样本进行了分析。研究人员结合成像技术、代谢组学、组织和单细胞转录组学对肝脏样本进行了分析。对患者进行了中位数为3年的随访，并根据其转移状态进行了分类。研究人员在PaC肝脏中发现了一些特征，可以预测转移结果，并将发生肝脏或肝外转移的患者与无病生存者区分开来。这些生物标志物包括中性粒细胞胞外陷阱的富集、T细胞小叶浸润、干扰素靶基因的过度表达以及CD11B+自然杀伤细胞的增加等。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metastatic pancreatic cancer and the liver

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.