高血清 miR-361-3p 预测自体干细胞移植术后出院早期感染。

IF 2.8 Q2 INFECTIOUS DISEASES
Infection and Chemotherapy Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI:10.3947/ic.2024.0021
Damian Mikulski, Kacper Kościelny, Izabela Dróżdż, Mateusz Nowicki, Małgorzata Misiewicz, Ewelina Perdas, Piotr Strzałka, Agnieszka Wierzbowska, Wojciech Fendler
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引用次数: 0

摘要

背景:自体造血干细胞移植(AHSCT自体造血干细胞移植(AHSCT)是目前治疗多发性骨髓瘤(MM)、复发性和难治性淋巴瘤的主要方法。值得注意的是,在术后最初的100天内,感染导致25%以上的AHSCT受者死亡。在这项研究中,我们旨在评估三种选定的 miRNA:hsa-miR-155-5p、hsa-miR-320c 和 hsa-miR-361-3p,以确定 AHSCT 受者在出院后移植后 100 天内发生感染事件的高风险:研究组由 58 名接受 AHSCT 治疗的患者(43 名 MM 患者,15 名淋巴瘤患者)组成。所有患者的血样均在同一时间点采集:移植后第 +14 天:15名患者(25.9%)在移植后出院后的最初100天内出现了感染并发症。感染发生的中位时间为 44 天(四分位数间距为 25-78)。四名患者因严重感染需要住院治疗。在出现感染并发症的患者中,hsa-miR-361-3p的高表达(折变[FC],1.79;P=0.0139)和hsa-miR-320c的过表达(FC,2.14;PP=0.0112)以及hsa-miR-361-3p的高表达(OR,3.00;95% CI,1.40-6.41;P=0.0047)是出院后感染并发症发生的独立相关因素。我们的模型在10倍交叉验证中保持了其诊断潜力,接收者操作特征曲线下面积为0.78(95% CI,0.64-0.92):血清hsa-miR-361-3p的升高有望成为一种生物标志物,用于识别出院后早期有感染风险的患者,从而有可能根据每位AHSCT受者的具体风险情况优化抗菌药物的预防性使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High Serum miR-361-3p Predicts Early Postdischarge Infections after Autologous Stem Cell Transplantation.

Background: Autologous hematopoietic stem cell transplantation (AHSCT) is currently the backbone of the treatment of multiple myeloma (MM) and relapsed and refractory lymphomas. Notably, infections contribute to over 25% of fatalities among AHSCT recipients within the initial 100 days following the procedure. In this study, we aimed to evaluate three selected miRNAs: hsa-miR-155-5p, hsa-miR-320c, and hsa-miR-361-3p, in identifying AHSCT recipients at high risk of infectious events up to 100 days post-transplantation after discharge.

Materials and methods: The study group consisted of 58 patients (43 with MM, 15 with lymphoma) treated with AHSCT. Blood samples were collected from all patients at the same time point: on day +14 after transplantation.

Results: Fifteen patients (25.9%) experienced infectious complications after post-transplant discharge within the initial +100 days post-transplantation. The median time to infection onset was 44 days (interquartile range, 25-78). Four patients required hospitalization due to severe infection. High expression of hsa-miR-361-3p (fold change [FC], 1.79; P=0.0139) in the patients experiencing infectious complications and overexpression of hsa-miR-320c (FC, 2.14; P<0.0001) in patients requiring hospitalization were observed. In the multivariate model, both lymphoma diagnosis (odds ratio [OR], 6.88; 95% confidence interval [CI], 1.55-30.56; P=0.0112) and high expression of hsa-miR-361-3p (OR, 3.00; 95% CI, 1.40-6.41; P=0.0047) were independent factors associated with post-discharge infectious complications occurrence. Our model in 10-fold cross-validation preserved its diagnostic potential with an area under the receiver operating characteristic curve of 0.78 (95% CI, 0.64-0.92).

Conclusion: Elevated serum hsa-miR-361-3p emerges as a promising biomarker for identifying patients at risk of infection during the early post-discharge period, potentially offering optimization of the prophylactic use of antimicrobial agents tailored to the specific risk profile of each AHSCT recipient.

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来源期刊
Infection and Chemotherapy
Infection and Chemotherapy INFECTIOUS DISEASES-
CiteScore
6.60
自引率
11.90%
发文量
71
审稿时长
22 weeks
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