成功的翻译。

IF 5.2 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Per Westermark, Giampaolo Merlini
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引用次数: 0

摘要

转化研究是推动系统性淀粉样变性诊断和治疗的关键。本文总结了我们在2023年9月25-26日于雅典举行的国际统计学会系统性淀粉样变性转化研讨会上的发言。本文回顾了该领域先驱们取得的重要进展,特别关注了对我们了解淀粉样蛋白是什么以及该物质如何影响功能至关重要的发现和发展。此外,还介绍了有关轻链淀粉样变性的心脏损伤机制、生物标志物在提高我们对疾病生物学和患者管理的认识方面的作用以及细胞毒性的分子机制等转化研究的实例。基础研究的进展将继续开辟新的治疗途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Successes in translation.

Translational research is key in advancing the diagnosis and therapy of systemic amyloidoses. This paper summarises our presentations at the ISA Workshop on Translation in Systemic Amyloidoses held in Athens on September 25-26, 2023. The critical advances made by the pioneers in the field are reviewed, with particular attention to the discoveries and developments of utmost importance to our understanding of what amyloid is and how the substance affects functions. Examples of translational research regarding the mechanisms of cardiac damage in light chain amyloidosis, the role of biomarkers in improving our understanding of the biology of the disease and patients' management, and the molecular mechanisms involved in the cytotoxicity are described. Advances in basic research continue to open new therapeutic avenues.

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来源期刊
Amyloid-Journal of Protein Folding Disorders
Amyloid-Journal of Protein Folding Disorders 生物-生化与分子生物学
CiteScore
10.60
自引率
10.90%
发文量
48
审稿时长
6-12 weeks
期刊介绍: Amyloid: the Journal of Protein Folding Disorders is dedicated to the study of all aspects of the protein groups and associated disorders that are classified as the amyloidoses as well as other disorders associated with abnormal protein folding. The journals major focus points are: etiology, pathogenesis, histopathology, chemical structure, nature of fibrillogenesis; whilst also publishing papers on the basic and chemical genetic aspects of many of these disorders. Amyloid is recognised as one of the leading publications on amyloid protein classifications and the associated disorders, as well as clinical studies on all aspects of amyloid related neurodegenerative diseases and major clinical studies on inherited amyloidosis, especially those related to transthyretin. The Journal also publishes book reviews, meeting reports, editorials, thesis abstracts, review articles and symposia in the various areas listed above.
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