{"title":"比较[18F]FDG PET/CT和[18F]FDG PET/MRI在检测心脏肉瘤病方面的诊断性能：荟萃分析。","authors":"","doi":"10.1016/j.clinimag.2024.110248","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [<sup>18</sup>F]FDG PET/CT and [<sup>18</sup>F]FDG PET/MRI in detecting cardiac sarcoidosis.</p></div><div><h3>Methods</h3><p>An extensive search was conducted in the PubMed and Embase databases to identify available publications up to November 2023. Studies were included if they evaluated the diagnostic efficacy of [<sup>18</sup>F]FDG PET/CT and [<sup>18</sup>F]FDG PET/MRI in patients with cardiac sarcoidosis. Sensitivity and specificity were evaluated using the DerSimonian and Laird method, with subsequent transformation via the Freeman-Tukey double inverse sine transformation. Publication bias was assessed using funnel plots and Egger's test.</p></div><div><h3>Results</h3><p>16 articles involving 1361 patients were included in the meta-analysis. The overall sensitivity of [<sup>18</sup>F]FDG PET/CT in detecting cardiac sarcoidosis was 0.77(95%CI: 0.62–0.89), while the overall sensitivity of [<sup>18</sup>F]FDG PET/MRI was 0.94(95%CI: 0.84–1.00). The result indicated that [<sup>18</sup>F]FDG PET/MRI appears to a higher sensitivity in comparison to [<sup>18</sup>F]FDG PET/CT(<em>P</em> = 0.02). In contrast, the overall specificity of [<sup>18</sup>F]FDG PET/CT in detecting cardiac sarcoidosis was 0.90(95%CI: 0.85–0.94), while the overall specificity of [<sup>18</sup>F]FDG PET/MRI was 0.79(95%CI: 0.53–0.96), with no significant difference in specificity (<em>P</em> = 0.32).</p></div><div><h3>Conclusions</h3><p>Our meta-analysis indicates that [<sup>18</sup>F]FDG PET/MRI demonstrates superior sensitivity and comparable specificity to [<sup>18</sup>F]FDG PET/CT in detecting cardiac sarcoidosis. However, the small number of PET/MRI studies limited the evidence of current results. To validate these results, larger, prospective studies employing a head-to-head design are needed.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparing the diagnostic performance of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting cardiac sarcoidosis: A meta-analysis\",\"authors\":\"\",\"doi\":\"10.1016/j.clinimag.2024.110248\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [<sup>18</sup>F]FDG PET/CT and [<sup>18</sup>F]FDG PET/MRI in detecting cardiac sarcoidosis.</p></div><div><h3>Methods</h3><p>An extensive search was conducted in the PubMed and Embase databases to identify available publications up to November 2023. Studies were included if they evaluated the diagnostic efficacy of [<sup>18</sup>F]FDG PET/CT and [<sup>18</sup>F]FDG PET/MRI in patients with cardiac sarcoidosis. Sensitivity and specificity were evaluated using the DerSimonian and Laird method, with subsequent transformation via the Freeman-Tukey double inverse sine transformation. Publication bias was assessed using funnel plots and Egger's test.</p></div><div><h3>Results</h3><p>16 articles involving 1361 patients were included in the meta-analysis. The overall sensitivity of [<sup>18</sup>F]FDG PET/CT in detecting cardiac sarcoidosis was 0.77(95%CI: 0.62–0.89), while the overall sensitivity of [<sup>18</sup>F]FDG PET/MRI was 0.94(95%CI: 0.84–1.00). The result indicated that [<sup>18</sup>F]FDG PET/MRI appears to a higher sensitivity in comparison to [<sup>18</sup>F]FDG PET/CT(<em>P</em> = 0.02). In contrast, the overall specificity of [<sup>18</sup>F]FDG PET/CT in detecting cardiac sarcoidosis was 0.90(95%CI: 0.85–0.94), while the overall specificity of [<sup>18</sup>F]FDG PET/MRI was 0.79(95%CI: 0.53–0.96), with no significant difference in specificity (<em>P</em> = 0.32).</p></div><div><h3>Conclusions</h3><p>Our meta-analysis indicates that [<sup>18</sup>F]FDG PET/MRI demonstrates superior sensitivity and comparable specificity to [<sup>18</sup>F]FDG PET/CT in detecting cardiac sarcoidosis. However, the small number of PET/MRI studies limited the evidence of current results. To validate these results, larger, prospective studies employing a head-to-head design are needed.</p></div>\",\"PeriodicalId\":50680,\"journal\":{\"name\":\"Clinical Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0899707124001785\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Imaging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0899707124001785","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Comparing the diagnostic performance of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting cardiac sarcoidosis: A meta-analysis
Purpose
This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in detecting cardiac sarcoidosis.
Methods
An extensive search was conducted in the PubMed and Embase databases to identify available publications up to November 2023. Studies were included if they evaluated the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with cardiac sarcoidosis. Sensitivity and specificity were evaluated using the DerSimonian and Laird method, with subsequent transformation via the Freeman-Tukey double inverse sine transformation. Publication bias was assessed using funnel plots and Egger's test.
Results
16 articles involving 1361 patients were included in the meta-analysis. The overall sensitivity of [18F]FDG PET/CT in detecting cardiac sarcoidosis was 0.77(95%CI: 0.62–0.89), while the overall sensitivity of [18F]FDG PET/MRI was 0.94(95%CI: 0.84–1.00). The result indicated that [18F]FDG PET/MRI appears to a higher sensitivity in comparison to [18F]FDG PET/CT(P = 0.02). In contrast, the overall specificity of [18F]FDG PET/CT in detecting cardiac sarcoidosis was 0.90(95%CI: 0.85–0.94), while the overall specificity of [18F]FDG PET/MRI was 0.79(95%CI: 0.53–0.96), with no significant difference in specificity (P = 0.32).
Conclusions
Our meta-analysis indicates that [18F]FDG PET/MRI demonstrates superior sensitivity and comparable specificity to [18F]FDG PET/CT in detecting cardiac sarcoidosis. However, the small number of PET/MRI studies limited the evidence of current results. To validate these results, larger, prospective studies employing a head-to-head design are needed.
期刊介绍：
The mission of Clinical Imaging is to publish, in a timely manner, the very best radiology research from the United States and around the world with special attention to the impact of medical imaging on patient care. The journal''s publications cover all imaging modalities, radiology issues related to patients, policy and practice improvements, and clinically-oriented imaging physics and informatics. The journal is a valuable resource for practicing radiologists, radiologists-in-training and other clinicians with an interest in imaging. Papers are carefully peer-reviewed and selected by our experienced subject editors who are leading experts spanning the range of imaging sub-specialties, which include:
-Body Imaging-
Breast Imaging-
Cardiothoracic Imaging-
Imaging Physics and Informatics-
Molecular Imaging and Nuclear Medicine-
Musculoskeletal and Emergency Imaging-
Neuroradiology-
Practice, Policy & Education-
Pediatric Imaging-
Vascular and Interventional Radiology
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