Jakob Ginsbak Notland, Helle K Iversen, Poul Jennum, Anders S West
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引用次数: 0
摘要
背景：由于多种原因，如原发疾病、并发症、药物、固定、日照减少和睡眠障碍等，脑卒中患者通常会出现昼夜节律紊乱：脑卒中患者常常因多种原因导致昼夜节律紊乱，如原发疾病、并发症、药物、固定、日照减少和睡眠障碍等：研究中重度脑卒中康复患者前额皮肤温度的昼夜节律：方法：通过对之前一项随机研究的二次分析，进行生理学研究。2014年5月1日至2015年6月1日期间，共有27名中重度中风患者被纳入研究。作为多导睡眠图（PSG）测量的一部分，通过皮肤表面温度探头收集入院后七天左右的昼夜体温：结果：体温变化未显示昼夜节律（通过 SAS 进行固定效应的类型 3 检验，p = 0.1610）。中位数体温方差确实有波动，但并不明显，昼夜节律体温方差的微小变化并不遵循正常体温方差：结论：中重度脑卒中患者的体温昼夜节律减弱。结论：中重度脑卒中患者的体温昼夜节律失调，其机制、对脑卒中预后和治疗的意义尚待了解。
Circadian Temperature in Moderate to Severe Acute Stroke Patients.
Background: Stroke patients often present circadian disruption due to multiple causes e.g., primary disease, comorbidities, medication, immobilization, reduced daylight entrainment and sleep disturbances.
Objective: To investigate the circadian rhythm of temperature in forehead skin in patients with moderate to severe stroke admitted for rehabilitation.
Methods: A physiologic study in form of a secondary analysis of a former randomized study. In total 27 patients with moderate to severe stroke were included between May 1st 2014, and June 1st 2015. Circadian temperature was collected approx. seven days after admission at the acute stroke unit by a skin surface temperature probe as part of a Polysomnography (PSG) measurement.
Results: Temperature variations show no circadian rhythm (Type 3 tests of fixed effects by SAS, p = 0.1610). The median temperature variance did fluctuate, but not significantly, and the small changes in circadian temperature variance did not follow the normal temperature variance.
Conclusion: Patients with moderate to severe stroke show an abrogated circadian rhythm of temperature. There is an unmet need to understand the mechanisms for this, significance for stroke outcome and treatment.
期刊介绍：
Journal of Circadian Rhythms is an Open Access, peer-reviewed online journal that publishes research articles dealing with circadian and nycthemeral (daily) rhythms in living organisms, including processes associated with photoperiodism and daily torpor. Journal of Circadian Rhythms aims to include both basic and applied research at any level of biological organization (molecular, cellular, organic, organismal, and populational). Studies of daily rhythms in environmental factors that directly affect circadian rhythms are also pertinent to the journal"s mission.
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