Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Lívia Gurgel do Amaral Valente Sá, Lisandra Juvêncio da Silva, João Batista de Andrade Neto, Cecília Rocha da Silva, Manoel Odorico de Moraes, Cláudio Costa Dos Santos, Hélio Vitoriano Nobre Júnior
{"title":"N-乙酰半胱氨酸和伊曲康唑增强了巴豆芹菜精油的抗杀虫活性。","authors":"Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Lívia Gurgel do Amaral Valente Sá, Lisandra Juvêncio da Silva, João Batista de Andrade Neto, Cecília Rocha da Silva, Manoel Odorico de Moraes, Cláudio Costa Dos Santos, Hélio Vitoriano Nobre Júnior","doi":"10.1080/17460913.2024.2380601","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> Evaluate the anticandidal effect of <i>Croton heliotropiifolius</i> Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms.<b>Materials & methods:</b> Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT.<b>Results:</b> The oil inhibited all <i>Candida</i> species growth. The activity was enhanced when associated with ITRA and NAC for planktonic cells and biofilms in formation. The effective concentrations were lower than the toxic ones to V79 cells.<b>Conclusion:</b> <i>C. heliotropiifolius</i> Kunth essential oil is an anticandidal alternative, and can be associated with ITRA and NAC.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485680/pdf/","citationCount":"0","resultStr":"{\"title\":\"Anticandidal activity of <i>Croton heliotropiifolius</i> Kunth essential oil is enhanced by N-acetylcysteine and itraconazole.\",\"authors\":\"Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Lívia Gurgel do Amaral Valente Sá, Lisandra Juvêncio da Silva, João Batista de Andrade Neto, Cecília Rocha da Silva, Manoel Odorico de Moraes, Cláudio Costa Dos Santos, Hélio Vitoriano Nobre Júnior\",\"doi\":\"10.1080/17460913.2024.2380601\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> Evaluate the anticandidal effect of <i>Croton heliotropiifolius</i> Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms.<b>Materials & methods:</b> Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT.<b>Results:</b> The oil inhibited all <i>Candida</i> species growth. The activity was enhanced when associated with ITRA and NAC for planktonic cells and biofilms in formation. The effective concentrations were lower than the toxic ones to V79 cells.<b>Conclusion:</b> <i>C. heliotropiifolius</i> Kunth essential oil is an anticandidal alternative, and can be associated with ITRA and NAC.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485680/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/17460913.2024.2380601\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17460913.2024.2380601","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Anticandidal activity of Croton heliotropiifolius Kunth essential oil is enhanced by N-acetylcysteine and itraconazole.
Aim: Evaluate the anticandidal effect of Croton heliotropiifolius Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms.Materials & methods: Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT.Results: The oil inhibited all Candida species growth. The activity was enhanced when associated with ITRA and NAC for planktonic cells and biofilms in formation. The effective concentrations were lower than the toxic ones to V79 cells.Conclusion:C. heliotropiifolius Kunth essential oil is an anticandidal alternative, and can be associated with ITRA and NAC.
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