鞘脂代谢酶是新陈代谢输入的转换器。

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Fabiola N Velazquez, Chiara Luberto, Daniel Canals, Yusuf A Hannun
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引用次数: 0

摘要

鞘磷脂(SL)是新陈代谢的一个独立子域,具有结构和信号功能。不断积累的证据还表明,中间代谢与鞘磷脂代谢之间存在密切联系。鉴于许多可溶性脂质具有生物活性(即传递信号),这就提出了一种可能性,即可溶性脂质的一个重要功能是将新陈代谢变化的信息传递给特定的细胞反应。这可能发生在不同层面。一些代谢物被纳入 SL,而另一些代谢物则可能启动调节或信号事件,进而调节 SL 的代谢。在这篇综述中,我们阐述了前者,因为它代表了 SL 代谢中一个鲜为人知的方面,我们提出了 SL 网络对几种特定代谢变化高度敏感的假设,重点是氨基酸(丝氨酸和丙氨酸)、各种脂肪酸、胆碱(和乙醇胺)和葡萄糖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enzymes of sphingolipid metabolism as transducers of metabolic inputs.

Sphingolipids (SLs) constitute a discrete subdomain of metabolism, and they display both structural and signaling functions. Accumulating evidence also points to intimate connections between intermediary metabolism and SL metabolism. Given that many SLs exhibit bioactive properties (i.e. transduce signals), these raise the possibility that an important function of SLs is to relay information on metabolic changes into specific cell responses. This could occur at various levels. Some metabolites are incorporated into SLs, whereas others may initiate regulatory or signaling events that, in turn, modulate SL metabolism. In this review, we elaborate on the former as it represents a poorly appreciated aspect of SL metabolism, and we develop the hypothesis that the SL network is highly sensitive to several specific metabolic changes, focusing on amino acids (serine and alanine), various fatty acids, choline (and ethanolamine), and glucose.

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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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