依达拉奉功能衍生物设计及其抗氧化活性探索的最新进展。

IF 3.9 2区 化学 Q2 CHEMISTRY, APPLIED
R Divya Mohan, Naveen V Kulkarni
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引用次数: 0

摘要

依达拉奉是一种吡唑酮衍生物,是一种抗氧化剂和自由基清除剂,用于治疗与氧化应激有关的疾病。它是一种行之有效的药物,可通过抑制脂质过氧化、减少炎症从而防止内皮细胞死亡,从而缓解氧化应激导致的疾病。近年来,研究人员对依达拉奉的衍生化产生了浓厚的兴趣,他们在依达拉奉中加入了各种具有多种立体和功能特性的取代基,以提高其抗氧化性和药理活性。本综述介绍了对依达拉奉进行衍生化的所有重要方法,以及结构修饰对其抗氧化活性的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent developments in the design of functional derivatives of edaravone and exploration of their antioxidant activities.

Recent developments in the design of functional derivatives of edaravone and exploration of their antioxidant activities.

Edaravone, a pyrazalone derivative, is an antioxidant and free radical scavenger used to treat oxidative stress-related diseases. It is a proven drug to mitigate conditions prevailing to oxidative stress by inhibiting lipid peroxidation, reducing inflammation, and thereby preventing endothelial cell death. In recent years, considerable interest has been given by researchers in the derivatization of edaravone by adding varieties of substituents of versatile steric and functional properties to improve its antioxidant and pharmacological activity. This review accounts all the important methods developed for the derivatization of edaravone and the impacts of the structural modifications on the antioxidant activity of the motif.

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来源期刊
Molecular Diversity
Molecular Diversity 化学-化学综合
CiteScore
7.30
自引率
7.90%
发文量
219
审稿时长
2.7 months
期刊介绍: Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;
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