治疗性核酸的内体逸出策略和机制。

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2024-08-01 DOI:10.1016/j.cbpa.2024.102506

Melina Grau , Ernst Wagner

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引用次数: 0

摘要

尽管近来治疗性核酸作为药物和疫苗的问世令人印象深刻，但由于其在细胞内输送方面的表现一般，影响了其在医学上的广泛应用。内质体逸出效率低是造成细胞货物释放不足的主要原因。根据载体的不同，这种内体屏障会严重限制甚至阻碍核酸的递送。本文综述了近期不同的内质体逸出策略及其假设机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Strategies and mechanisms for endosomal escape of therapeutic nucleic acids

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Strategies and mechanisms for endosomal escape of therapeutic nucleic acids

Despite impressive recent establishment of therapeutic nucleic acids as drugs and vaccines, their broader medical use is impaired by modest performance in intracellular delivery. Inefficient endosomal escape presents a major limitation responsible for inadequate cytosolic cargo release. Depending on the carrier, this endosomal barrier can strongly limit or even abolish nucleic acid delivery. Different recent endosomal escape strategies and their hypothesized mechanisms are reviewed.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.