多酮生物合成的环化和氧化的最新进展。

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Bo Zhang, Hui Ming Ge
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引用次数: 0

摘要

多酮类化合物是一类重要的天然产品,以其复杂的结构和多样的生物活性而闻名于世。与普通脂肪酸相比,多酮化合物具有相对更坚硬的碳骨架、更复杂的环系统和手性中心。这些结构特征主要是通过独特的酶环化和氧化作为定制步骤实现的。在本报告中,我们将讨论在破译多酮生物合成过程中的环化和氧化机制方面取得的最新进展。通过揭示这些酶促过程,这篇文章力图激励社会各界揭开围绕环化酶和氧化酶功能的未解之谜,并通过基因组挖掘探索新型多酮天然产物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent progresses in the cyclization and oxidation of polyketide biosynthesis

Polyketides represent an important class of natural products, renowned for their intricate structures and diverse biological activities. In contrast to common fatty acids, polyketides possess relatively more rigid carbon skeletons, more complex ring systems, and chiral centers. These structural features are primarily achieved through distinctive enzymatic cyclizations and oxidations as tailoring steps. In this opinion, we discuss the recent progress in deciphering the mechanisms of cyclization and oxidation within polyketide biosynthesis. By shedding light on these enzymatic processes, this article seeks to motivate the community to unravel the remaining mysteries surrounding cyclase and oxidase functionalities and to explore novel polyketide natural products through genome mining.

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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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