澳大利亚和非洲不同啮齿动物物种中的 GALV-KoRV 相关逆转录病毒。

IF 5.5 2区医学 Q1 VIROLOGY

Virus Evolution Pub Date : 2024-08-01 DOI:10.1093/ve/veae061

Joshua A Hayward, Shuoshuo Tian, Gilda Tachedjian

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引用次数: 0

摘要

长臂猿白血病病毒（GALV）及其近亲考拉逆转录病毒（KoRV）的神秘起源和传播事件一直备受争议。蝙蝠和啮齿类动物分别被认为是种间传播的主要贮源，人们还在努力确定 GALV-KoRV 相关逆转录病毒的其他动物宿主。在这项研究中，我们发现了九种啮齿类动物是 GALV-KoRV 相关逆转录病毒的新型宿主。这些宿主中包括两种非洲啮齿动物，揭示了该支系首次出现在澳大利亚和东南亚地区以外的地方。其中一种非洲啮齿类动物--Mastomys natalensis--携带的内源性 GALV-KoRV 相关逆转录病毒是完全完整的，并且仍具有潜在的传染性。我们的发现支持了啮齿类动物是 GALV-KoRV 相关逆转录病毒主要携带者的假设。

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GALV-KoRV-related retroviruses in diverse Australian and African rodent species.

The enigmatic origins and transmission events of the gibbon ape leukemia virus (GALV) and its close relative, the koala retrovirus (KoRV) have been a source of enduring debate. Bats and rodents are each proposed as major reservoirs of interspecies transmission, with ongoing efforts to identify additional animal hosts of GALV-KoRV-related retroviruses. In this study, we identified nine rodent species as novel hosts of GALV-KoRV-related retroviruses. Included among these hosts are two African rodents, revealing the first appearance of this clade beyond the Australian and Southeast Asian region. One of these African rodents, Mastomys natalensis, carries an endogenous GALV-KoRV-related retrovirus that is fully intact and potentially still infectious. Our findings support the hypothesis that rodents are the major carriers of GALV-KoRV-related retroviruses.

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来源期刊

Virus Evolution Immunology and Microbiology-Microbiology

CiteScore

10.50

自引率

5.70%

发文量

108

审稿时长

14 weeks

期刊介绍： Virus Evolution is a new Open Access journal focusing on the long-term evolution of viruses, viruses as a model system for studying evolutionary processes, viral molecular epidemiology and environmental virology. The aim of the journal is to provide a forum for original research papers, reviews, commentaries and a venue for in-depth discussion on the topics relevant to virus evolution.