增强三维打印生物相容性聚(乳酸)锁定骨板的冲击和扭转性能:可持续地融入医疗保健应用中

IF 2.9 4区 化学 Q2 POLYMER SCIENCE
Shrutika Sharma, Vishal Gupta, Deepa Mudgal
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引用次数: 0

摘要

锁定骨板(LoBPs)在骨科手术中用于支撑尺骨远端骨折的部分。锁定骨板主要由金属生物材料制成,其硬度远高于天然骨骼,会产生应力屏蔽,而且容易腐蚀。因此,越来越多的人倾向于使用生物相容性和可生物降解的高分子生物材料,利用三维打印技术制作患者专用的植入体。在各种生物材料中,聚乳酸(PLA)因其良好的生物相容性和生物可降解性而脱颖而出。这种工艺中的逐层沉积会引起层间粘合问题,从而降低植入物的机械强度。然而,调整工艺参数可以提高生产部件的机械强度。本研究旨在利用响应面方法研究印刷参数对生物相容性和可生物降解聚乳酸基 LoBPs 的冲击强度和扭矩承受能力的影响。实验结果表明,增加填充密度和壁厚可最大限度地减少孔隙率,增强层间结合力,从而获得较高的抗冲击和抗扭转能力。相反,层高和印刷速度的增加会诱发孔隙率,导致层在突然的冲击力和扭转力作用下提前断裂。使用扫描电镜分析了 LoBPs 在冲击和扭转测试后的断裂表面形态。通过基于 MATLAB 的优化,冲击强度和扭矩的最大值分别为 27.175 kJ m-2 和 3644 N mm。该研究强调了基于聚乳酸的生物相容性和生物可降解三维打印 LoBPs 在生物医学应用中可持续集成的潜力。© 2024 化学工业协会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancement in the impact and torsional properties of 3D‐printed biocompatible poly(lactic acid) locking bone plates: sustainable integration into healthcare applications
Locking bone plates (LoBPs) are utilized in orthopedic surgeries for supporting segments of distal ulna fracture. Primarily constructed from metallic biomaterials that are much stiffer than natural bone, LoBPs result in stress shielding and are prone to corrosion. As a result, there has been a growing preference for biocompatible and biodegradable polymeric biomaterials for creating patient‐specific implants using 3D printing. Among various biomaterials, poly(lactic acid) (PLA) stands out due to its favorable biocompatibility and biodegradability. The layer‐by‐layer deposition in this process raises issues about layer bonding, reducing the mechanical strength of the implants. Nevertheless, adjusting process parameters can enhance the mechanical strength of the produced parts. The current study aimed to examine the influence of printing parameters on the impact strength and torque withstanding ability of biocompatible and biodegradable PLA‐based LoBPs using response surface methodology. The experimental results reveal that an increase in infill density and wall thickness minimize porosity and enhance inter‐layer bonding, imparting high impact and torsional resistance against forces. Conversely, an increase in layer height and printing speed induces porosity, leading to early fracture of layers under sudden impact and torsional forces. The fractured surface morphology of LoBPs after impact and torsional testing was analyzed using SEM. The MATLAB‐based optimization yielded maximum impact strength and torque values of 27.175 kJ m−2 and 3644 N mm, respectively. The study underscores the potential of biocompatible and biodegradable PLA‐based 3D‐printed LoBPs for sustainable integration into biomedical applications. © 2024 Society of Chemical Industry.
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来源期刊
Polymer International
Polymer International 化学-高分子科学
CiteScore
7.10
自引率
3.10%
发文量
135
审稿时长
4.3 months
期刊介绍: Polymer International (PI) publishes the most significant advances in macromolecular science and technology. PI especially welcomes research papers that address applications that fall within the broad headings Energy and Electronics, Biomedical Studies, and Water, Environment and Sustainability. The Journal’s editors have identified these as the major challenges facing polymer scientists worldwide. The Journal also publishes invited Review, Mini-review and Perspective papers that address these challenges and others that may be of growing or future relevance to polymer scientists and engineers.
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