利用新型亲水相互作用液相色谱 (HILIC) 和捕获离子迁移质谱 (TIMS) 及荧光检测 (FLD) 鉴定单克隆抗体的 N-糖构象

IF 1.6 4区化学 Q3 CHEMISTRY, ANALYTICAL

Analytical Letters Pub Date : 2024-07-29 DOI:10.1080/00032719.2024.2384700

İzzet Avcı, Mehmet Atakay, Hacı Mehmet Kayılı, Bekir Salih

引用次数: 0

摘要

单克隆抗体 (mAbs) 已成为制药行业治疗各种疾病的常用药物，在市场上占有重要地位。这些分子的测定非常复杂...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Characterization of Monoclonal Antibody N-Glycan Conformations by Novel Hydrophilic Interaction Liquid Chromatography (HILIC) with Trapped Ion Mobility Mass Spectrometry (TIMS) and Fluorescence Detection (FLD)

Monoclonal antibodies (mAbs) have become prevalent in the pharmaceutical sector for treating various diseases and have a significant market presence. The determination of these molecules is complex...

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来源期刊

Analytical Letters 化学-分析化学

CiteScore

4.10

自引率

5.00%

发文量

218

审稿时长

2.1 months

期刊介绍： Analytical Letters is an international medium for the rapid publication of original research papers, accelerated articles, or mini-reviews on important developments in all areas of analytical chemistry, including electrochemistry, mass spectrometry, separations, and spectroscopy. Papers are welcomed that consider fundamental developments, new or improved instrumentation and sensors, and applications of analytical chemistry in all areas that include biological and clinical science, engineering and instrumentation science, environmental chemistry and analysis, geochemistry, materials science, nanotechnology, and physics.