利用新型亲水相互作用液相色谱 (HILIC) 和捕获离子迁移质谱 (TIMS) 及荧光检测 (FLD) 鉴定单克隆抗体的 N-糖构象

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-29 DOI:10.1080/00032719.2024.2384700

İzzet Avcı, Mehmet Atakay, Hacı Mehmet Kayılı, Bekir Salih

引用次数: 0

摘要

单克隆抗体 (mAbs) 已成为制药行业治疗各种疾病的常用药物，在市场上占有重要地位。这些分子的测定非常复杂...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Characterization of Monoclonal Antibody N-Glycan Conformations by Novel Hydrophilic Interaction Liquid Chromatography (HILIC) with Trapped Ion Mobility Mass Spectrometry (TIMS) and Fluorescence Detection (FLD)

Monoclonal antibodies (mAbs) have become prevalent in the pharmaceutical sector for treating various diseases and have a significant market presence. The determination of these molecules is complex...

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.