BF3‧OEt2 促进从（苯乙炔基）-芴和 2-肼基吡啶衍生物合成 9-亚芴基 2-肼基吡啶亚胺的过程

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-08-01 DOI:10.1080/00397911.2024.2385538

Suresh Snoxma Smile , Harichandran Gurusamy , Ponnusamy Shanmugam

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引用次数: 0

摘要

以BF3-OEt2为路易斯酸催化剂，使9-芴丙炔醇与取代的2-肼基吡啶反应，得到9-芴亚甲基2-肼基吡啶亚胺衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BF3‧OEt2 promoted synthesis of 9-fluorenlidene appended 2-hydrazinopyridine imines from (phenylethynyl)-fluorene and 2-hydrazinopyridine derivatives

Reaction of 9-fluorene propargylic alcohols and substituted-2-hydrazinopyridine using BF₃·OEt₂ as a Lewis acid catalyst afforded 9-fluorenlidene appended 2-hydrazinopyridine imine derivatives has been developed. The scope of the reaction is demonstrated by selecting a range of fluorene propargylic alcohols and substituted 2-hydrazinopyridine imines. All the synthesized molecules were characterized using various spectroscopic and analytical techniques including ¹H NMR,¹³C NMR, and Mass spectrometry. A plausible reaction mechanism for forming title compounds via propargylic allenyl carbocation is postulated. The synthetic utility of products thus formed is demonstrated by utilizing Suzuki coupling.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.