针对 GI-23 系传染性支气管炎病毒挑战的不同异源同种疫苗方案评估

IF 2.8 3区 医学 Q3 VIROLOGY
Mohamed H. Houta , Kareem E. Hassan , Walid H. Kilany , Salama A.S. Shany , Azza A. El-Sawah , Magdy F. ElKady , Ahmed S. Abdel-Moneim , Ahmed Ali
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引用次数: 0

摘要

本研究评估了使用市售 GI-23(埃及-VAR2)和 GI-1(H120)减毒活疫苗接种肉鸡的不同 IBV 疫苗方案。疫苗分别在 1 日龄、14 日龄接种,或同时接种两种疫苗。在 28 日龄接种野生型 VAR2 后进行的纤溶试验表明,在 1 日龄接种传统的 H120+VAR2 疫苗,然后在 14 日龄接种 VAR2 疫苗可提供最高水平的保护(89.58%)。同样,1日龄时接种VAR2疫苗,14日龄时接种经典H120疫苗,也能提供相当高的保护率(85.42%)。相反,仅在 1 日龄时注射经典 H120 和 VAR2 的保护率最低(54.17%)。与未接种疫苗的挑战组相比,接种疫苗组的气管病毒脱落定量以及气管和肾脏退行性变化评估结果均显著降低。总之,基于同源疫苗接种的精心策划的疫苗接种方案可为肉鸡提供最有效的临床保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of different heterologous-homologous vaccine regimens against challenge with GI-23 lineage infectious bronchitis virus

This study assesses different IBV vaccination regimens in broiler chickens using commercially available live attenuated GI-23 (Egyptian-VAR2) and GI-1 (H120) vaccines. Vaccines were administered at 1, 14 days of age, or both. The ciliostasis test, following wild-type VAR2 challenge at 28 days of age, indicated that classic H120+VAR2 at one day old followed by the VAR2 vaccine at 14 days of age provided the highest level of protection (89.58%). Similarly, administering VAR2 at 1 day of age and classic H120 at 14 days of age demonstrated substantial protection (85.42%). Conversely, administering only classic H120 and VAR2 at one day old resulted in the lowest protection level (54.17%). Tracheal virus shedding quantification and assessment of trachea and kidney degenerative changes were significantly lower in vaccinated groups compared to the unvaccinated-challenged group. In conclusion, a carefully planned vaccination regimen based on homologous vaccination offers the most effective clinical protection in broiler chickens.

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来源期刊
Virology
Virology 医学-病毒学
CiteScore
6.00
自引率
0.00%
发文量
157
审稿时长
50 days
期刊介绍: Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.
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