Matheus Silvério Mattos, Sofie Vandendriessche, Ari Waisman, Pedro Elias Marques
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引用次数: 0
摘要
B-1 细胞具有复杂的生物学特性，其功能、表型和发育起源与传统 B 细胞截然不同。它们产生的 B 细胞受体具有保守的种系特征和偏向 V(D)J 重组，使这种天生的类淋巴细胞能够自发产生自我反应性天然抗体（NAbs），并以不依赖 T 细胞的方式被免疫刺激激活。NAbs 被认为是老年慢性病的 "调节器"。事实上，NAbs随年龄增长而丧失功能与临床相关的老年疾病（如动脉粥样硬化和神经退行性疾病）有关。在这里，我们全面分析了 B-1 细胞和 NAbs 的本体、表型特征、功能特性以及在健康和疾病中的新作用。此外，在了解了 B-1 细胞从发育到衰老的复杂生物学过程后，我们还讨论了该领域的治疗机会。
The immunology of B-1 cells: from development to aging.
B-1 cells have intricate biology, with distinct function, phenotype and developmental origin from conventional B cells. They generate a B cell receptor with conserved germline characteristics and biased V(D)J recombination, allowing this innate-like lymphocyte to spontaneously produce self-reactive natural antibodies (NAbs) and become activated by immune stimuli in a T cell-independent manner. NAbs were suggested as "rheostats" for the chronic diseases in advanced age. In fact, age-dependent loss of function of NAbs has been associated with clinically-relevant diseases in the elderly, such as atherosclerosis and neurodegenerative disorders. Here, we analyzed comprehensively the ontogeny, phenotypic characteristics, functional properties and emerging roles of B-1 cells and NAbs in health and disease. Additionally, after navigating through the complexities of B-1 cell biology from development to aging, therapeutic opportunities in the field are discussed.
期刊介绍：
Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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