Tiago Bertola Lobato, Richelieau Manoel, Ana Carolina Gomes Pereira, Ilana Souza Correa, Patrícia Nancy Iser-Bem, Elvirah Samantha de Sousa Santos, Joice Naiara Bertaglia Pereira, Maria Janaína Leite de Araújo, João Carlos de Oliveira Borges, Janaina Ribeiro Barbosa Pauferro, Vinicius Leonardo Sousa Diniz, Maria Vitória Martins Scervino, Tamires Duarte Serdan, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi, Renata Gorjão
{"title":"非肥胖型 2 型糖尿病后藤柿崎大鼠的胰岛素抵抗与促炎性 T 淋巴细胞特征有关。","authors":"Tiago Bertola Lobato, Richelieau Manoel, Ana Carolina Gomes Pereira, Ilana Souza Correa, Patrícia Nancy Iser-Bem, Elvirah Samantha de Sousa Santos, Joice Naiara Bertaglia Pereira, Maria Janaína Leite de Araújo, João Carlos de Oliveira Borges, Janaina Ribeiro Barbosa Pauferro, Vinicius Leonardo Sousa Diniz, Maria Vitória Martins Scervino, Tamires Duarte Serdan, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi, Renata Gorjão","doi":"10.1002/1873-3468.14977","DOIUrl":null,"url":null,"abstract":"<p><p>Goto-Kakizaki (GK) rats develop a well-defined insulin resistance (IR) and type 2 diabetes mellitus (T2DM) without presenting obesity. The lymphocyte profile in nonobese diabetic conditions is not yet characterized. Therefore, GK rats were chosen to explore T lymphocyte (TL) dynamics at various stages (21, 60, and 120 days) compared to Wistar rats. GK rats exhibit progressive disruption of glucose regulation, with early glucose intolerance at 21 days and reduced insulin sensitivity at 60 days, confirming IR. Glucose transporter 1 (GLUT1) expression was consistently elevated in GK rats, suggesting heightened TL activation. T-regulatory lymphocyte markers diminished at 21 days. However, GK rats showed increased Th1 markers and reduced Gata-3 expression (crucial for Th2 cell differentiation) at 120 days. These findings underscore an early breakdown of anti-inflammatory mechanisms in GK rats, indicating a proinflammatory TL profile that may worsen chronic inflammation in T2DM.</p>","PeriodicalId":12142,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Insulin resistance in nonobese type 2 diabetic Goto Kakizaki rats is associated with a proinflammatory T lymphocyte profile.\",\"authors\":\"Tiago Bertola Lobato, Richelieau Manoel, Ana Carolina Gomes Pereira, Ilana Souza Correa, Patrícia Nancy Iser-Bem, Elvirah Samantha de Sousa Santos, Joice Naiara Bertaglia Pereira, Maria Janaína Leite de Araújo, João Carlos de Oliveira Borges, Janaina Ribeiro Barbosa Pauferro, Vinicius Leonardo Sousa Diniz, Maria Vitória Martins Scervino, Tamires Duarte Serdan, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi, Renata Gorjão\",\"doi\":\"10.1002/1873-3468.14977\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Goto-Kakizaki (GK) rats develop a well-defined insulin resistance (IR) and type 2 diabetes mellitus (T2DM) without presenting obesity. The lymphocyte profile in nonobese diabetic conditions is not yet characterized. Therefore, GK rats were chosen to explore T lymphocyte (TL) dynamics at various stages (21, 60, and 120 days) compared to Wistar rats. GK rats exhibit progressive disruption of glucose regulation, with early glucose intolerance at 21 days and reduced insulin sensitivity at 60 days, confirming IR. Glucose transporter 1 (GLUT1) expression was consistently elevated in GK rats, suggesting heightened TL activation. T-regulatory lymphocyte markers diminished at 21 days. However, GK rats showed increased Th1 markers and reduced Gata-3 expression (crucial for Th2 cell differentiation) at 120 days. These findings underscore an early breakdown of anti-inflammatory mechanisms in GK rats, indicating a proinflammatory TL profile that may worsen chronic inflammation in T2DM.</p>\",\"PeriodicalId\":12142,\"journal\":{\"name\":\"FEBS Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FEBS Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1002/1873-3468.14977\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEBS Letters","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/1873-3468.14977","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Insulin resistance in nonobese type 2 diabetic Goto Kakizaki rats is associated with a proinflammatory T lymphocyte profile.
Goto-Kakizaki (GK) rats develop a well-defined insulin resistance (IR) and type 2 diabetes mellitus (T2DM) without presenting obesity. The lymphocyte profile in nonobese diabetic conditions is not yet characterized. Therefore, GK rats were chosen to explore T lymphocyte (TL) dynamics at various stages (21, 60, and 120 days) compared to Wistar rats. GK rats exhibit progressive disruption of glucose regulation, with early glucose intolerance at 21 days and reduced insulin sensitivity at 60 days, confirming IR. Glucose transporter 1 (GLUT1) expression was consistently elevated in GK rats, suggesting heightened TL activation. T-regulatory lymphocyte markers diminished at 21 days. However, GK rats showed increased Th1 markers and reduced Gata-3 expression (crucial for Th2 cell differentiation) at 120 days. These findings underscore an early breakdown of anti-inflammatory mechanisms in GK rats, indicating a proinflammatory TL profile that may worsen chronic inflammation in T2DM.
期刊介绍：
FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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