正确应用抗凝疗法治疗癌症相关静脉血栓。

IF 2.3 Q2 HEMATOLOGY
Ho-Young Yhim
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引用次数: 0

摘要

癌症相关静脉血栓栓塞症(VTE)严重影响发病率和死亡率。过去十年中,直接口服抗凝剂的引入彻底改变了活动性癌症患者的 VTE 治疗,与传统疗法相比具有潜在优势。然而,抗凝剂的最佳选择和剂量仍存在不确定性,尤其是对于具有特定出血风险因素的患者,如某些癌症类型(如上消化道癌症、泌尿生殖系统癌症、原发性或转移性脑肿瘤以及血液系统恶性肿瘤)和特定患者特征(如肾功能障碍和血小板减少症)。有关低血栓负荷 VTE(如亚段肺栓塞和孤立的远端深静脉血栓)相关血栓风险的最新数据强调了在日常临床实践中更新管理策略的必要性。本综述旨在探讨这些问题,并强调癌症相关 VTE 管理的演变情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proper application of anticoagulation therapy on cancer-associated venous thrombosis.

Cancer-associated venous thromboembolism (VTE) significantly impacts morbidity and mortality. The introduction of direct oral anticoagulants over the past decade has revolutionized VTE treatment in patients with active cancer, offering potential advantages over traditional therapies. However, uncertainties persist regarding the optimal selection and dosage of anticoagulants, particularly in patients with specific risk factors for bleeding, such as certain cancer types (e.g., upper gastrointestinal cancer, genitourinary cancer, primary or metastatic brain tumor, and hematologic malignancies) and specific patient characteristics (e.g., renal dysfunction and thrombocytopenia). Recent data on the thrombotic risk associated with low thrombotic burden VTE, such as subsegmental pulmonary embolism and isolated distal deep vein thrombosis, underscore the need for updated management strategies in daily clinical practice. This review aims to explore these issues and highlight the evolving landscape of cancer-associated VTE management.

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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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