在埃塞俄比亚西北部贡德尔市 Poly 和 Maraki 健康中心就诊的临床疑似患者中,乙型和丙型肝炎血清流行率及其相关风险因素。

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
SAGE Open Medicine Pub Date : 2024-07-30 eCollection Date: 2024-01-01 DOI:10.1177/20503121241266347
Solomon Tesfaye, Adefework Alemu, Endalkachew Bizualem, Daniel Mehabie, Amir Alelign
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引用次数: 0

摘要

背景:乙型肝炎和丙型肝炎病毒是全球主要的健康问题,死亡率很高,主要是由于肝硬化、肝功能衰竭和肝细胞癌等严重肝病引起的。本研究旨在确定在贡德尔市 Poly 和 Maraki 健康中心就诊的临床疑似患者中乙型肝炎和丙型肝炎病毒的流行情况及相关风险因素:在 2020 年 6 月至 8 月期间,对前往 Poly 和 Maraki 卫生中心就诊的 422 名临床疑似患者进行了一项基于机构的横断面研究。使用市售快速检测试剂盒对血样进行乙型肝炎表面抗原和抗丙型肝炎病毒抗体检测。我们使用逻辑回归和卡方分析来评估与乙型肝炎病毒和丙型肝炎病毒感染相关的因素:结果:乙型肝炎表面抗原和抗丙型肝炎病毒抗体的总体流行率分别为 29(6.9%)和 5(1.2%)。在马拉基医疗中心,乙型肝炎病毒和丙型肝炎病毒的感染率明显较高。多个性伴侣(调整后的奇异比(AOR = 12.299;95% CI = 2.515-60.142)、传统助产士接生史(AOR = 6.284;95% CI = 2.373-16.637)、手术史(AOR = 3.679;95% CI = 1.009-13.417)、既往肝炎感染(AOR = 10.374;95% CI = 1.128-95.444)和上腹部疼痛(AOR = 3.382;95% CI = 1.215-9.414)与乙型肝炎病毒感染风险增加显著相关。另一方面,输血史(AOR = 43.132;95% CI = 1.385-1343.176)和肾透析史(AOR = 71.199;95% CI = 2.074-2444.646)与丙型肝炎病毒感染显著相关:结论:根据世界卫生组织流行病学分类,乙型肝炎病毒感染率处于中等水平,而丙型肝炎病毒感染率较低。因此,有必要加强对乙型肝炎病毒和丙型肝炎病毒感染的控制和预防。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seroprevalence of hepatitis B, C, and its associated risk factors among clinically suspected patients attending poly and Maraki Health Centers, Gondar City, North West Ethiopia.

Background: Hepatitis B and C viruses are major global health problems with a high mortality rate, mostly due to serious liver diseases such as liver cirrhosis, liver failure, and hepatocellular carcinoma. The objective of this study was to determine the prevalence of the hepatitis B and C viruses and associated risk factors among clinically suspected patients attending Poly and Maraki Health Centers in Gondar City.

Methods: An institution-based cross-sectional study was conducted to recruit 422 clinically suspected patients attending Poly and Maraki Health Centers between June and August 2020. The blood sample was tested for hepatitis B surface antigen and anti-Hepatitis C virus antibodies using commercially available rapid test kits. We used logistic regression and chi-square analysis to assess factors associated with Hepatitis B virus and Hepatitis C virus infections.

Results: The overall prevalence of hepatitis B surface antigen and anti-Hepatitis C virus antibodies was 29 (6.9%) and 5 (1.2%), respectively. The prevalence of Hepatitis B virus and Hepatitis C virus was found to be significantly higher at Maraki Health Center. Multiple sexual partners (adjusted odd ratio (AOR = 12.299; 95% CI = 2.515-60.142), history of delivery by traditional birth attendants (AOR = 6.284; 95% CI = 2.373-16.637), surgical history (AOR = 3.679; 95% CI = 1.009-13.417), previous hepatitis infections (AOR = 10.374; 95% CI = 1.128-95.444), and upper abdominal pain (AOR = 3.382; 95% CI = 1.215-9.414) were significantly associated with an increased risk of Hepatitis B virus infections. On the other hand, a history of blood transfusion (AOR = 43.132; 95% CI = 1.385-1343.176) and a history of kidney dialysis (AOR = 71.199; 95% CI = 2.074-2444.646) were significantly associated with Hepatitis C virus infection.

Conclusions: According to the WHO endemicity classification, the prevalence of the hepatitis B virus was intermediate, while that of the hepatitis C virus was low. Therefore, it is necessary to strengthen the efforts to control and prevent Hepatitis B virus and Hepatitis C virus infections.

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SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
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4.30%
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289
审稿时长
12 weeks
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