前列腺癌病灶治疗后的挽救治疗--全面回顾。

IF 5.1 2区 医学 Q1 ONCOLOGY
Lorenzo Storino Ramacciotti, Andre Luis Abreu, Sébastien Crouzet, Petr Macek, Brian J Miles, Rahim Horuz, Diogo Nunes-Carneiro, Phillip Stricker, Stephen Scionti, M Pilar Laguna
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引用次数: 0

摘要

目的回顾前列腺癌(PCa)病灶治疗(FT)后挽救治疗的文献:截至 2024 年 3 月 15 日,我们在 PubMed、Scopus 和 Web of Science 上对评估原发性前列腺癌病灶治疗后复发 PCa 患者挽救治疗结果的研究进行了非系统性文献综述。纳入患者人数超过 10 人的原创前瞻性和回顾性研究。综述、编辑评论、会议摘要以及仅关注全腺治疗的研究均被排除在外:结果:共纳入 21 项研究,患者总数达 1012 人。报道最多的挽救治疗方法是挽救性前列腺癌根治术,然后再进行消融治疗。只有一项研究对挽救性放射治疗进行了评估。除一项前瞻性研究外,其他研究均为回顾性研究。肿瘤学结果显示生化复发率可以接受。功能性结果各不相同,各种模式对勃起功能都有显著影响,但对尿失禁率的影响较小。所有治疗方案的并发症普遍较低:结论:原发性前列腺癌术后的挽救治疗是可行的、安全的,并具有合理的肿瘤治疗效果。结论:原发性前列腺癌术后的挽救性治疗是可行的、安全的,并且具有合理的肿瘤治疗效果。然而,性功能明显下降是常见现象,而尿失禁受到的影响相对较小。文献主要由回顾性研究组成;因此,未来的研究应侧重于大规模的前瞻性评估,以更好地确定治疗方案并改善患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Salvage treatments after focal therapy for prostate cancer - a comprehensive review.

Salvage treatments after focal therapy for prostate cancer - a comprehensive review.

Objective: To review the literature on salvage treatments after focal therapy (FT) for prostate cancer (PCa).

Materials and methods: A non-systematic literature review was conducted on PubMed, Scopus, and Web of Science up to March 15, 2024, for studies that assessed salvage treatment outcomes in patients with recurrent PCa after primary FT. Original prospective and retrospective studies with more than 10 patients were included. Reviews, editorial comments, conference abstracts, and studies focusing solely on whole-gland treatments were excluded.

Results: Twenty-one studies with a total of 1012 patients were included. The most reported salvage treatments were salvage radical prostatectomy followed by re-do ablation therapy. Only one study evaluated salvage radiation therapy. Except for one prospective study, all studies were retrospective. Oncological outcomes showed acceptable biochemical recurrence rates. Functional outcomes varied, with significant impacts observed on erectile function across modalities, though continence rates were less impacted. Complications were generally low across all treatment options.

Conclusion: Salvage treatment post-primary FT is feasible, safe, and has reasonable oncologic outcomes. However, significant declines in sexual function are common, while continence is comparatively less affected. The literature primarily consists of retrospective studies; hence, future research should focus on large-scale prospective evaluations to better define treatment protocols and improve patient outcomes.

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来源期刊
Prostate Cancer and Prostatic Diseases
Prostate Cancer and Prostatic Diseases 医学-泌尿学与肾脏学
CiteScore
10.00
自引率
6.20%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Prostate Cancer and Prostatic Diseases covers all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. Prostate Cancer and Prostatic Diseases publishes original research articles, reviews, topical comment and critical appraisals of scientific meetings and the latest books. The journal also contains a calendar of forthcoming scientific meetings. The Editors and a distinguished Editorial Board ensure that submitted articles receive fast and efficient attention and are refereed to the highest possible scientific standard. A fast track system is available for topical articles of particular significance.
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