新生儿先天性梅毒症状的相关因素。

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria Pub Date : 2024-07-29 DOI:10.1016/j.jped.2024.06.008

Ana Fátima Braga Rocha , Maria Alix Leite Araújo , Aisha Khizar Yousafzai , Rebeca Gomes de Oliveira , Ana Patrícia Alves da Silva

{"title":"新生儿先天性梅毒症状的相关因素。","authors":"Ana Fátima Braga Rocha , Maria Alix Leite Araújo , Aisha Khizar Yousafzai , Rebeca Gomes de Oliveira , Ana Patrícia Alves da Silva","doi":"10.1016/j.jped.2024.06.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To analyze risk factors (maternal, obstetric and demographic) associated with congenital syphilis and the clinical characteristics of the newborns.</div></div><div><h3>Method</h3><div>A cross-sectional study carried out in ten public maternity hospitals in Fortaleza, Ceará, Brazil that included cases of live births reported with congenital syphilis in 2015.</div></div><div><h3>Results</h3><div>469 cases were analyzed; 199 (42.4 %) showed some sign or symptom suggestive of congenital syphilis; of these, 65 (32.7 %) were preterm, 87 (43.7 %) had low birth weight, 116 (58.3 %) had jaundice that required phototherapy, 13 (6.5 %) had hepatomegaly, 10 (5 %) had skin lesions, eight (4.0 %) had splenomegaly and one (0.5 %) had limb pseudoparalysis. Records of other clinical changes were identified in 36 (7.7 %) children. Children whose mothers were not treated or who received a drug other than penicillin and those whose mothers had a VDRL titer ≥ 1:16 at birth were 3.7 and 3.2 times more likely to be born with signs of congenital syphilis (<em>p</em> < 0.001- 95 % CI 2.41–5.58; <em>p</em> < 0.001 – 95 % CI 2.41–5.58) respectively.</div></div><div><h3>Conclusions</h3><div>The findings of this study draw attention to the importance of improving the quality of prenatal care and the development of studies aimed at finding alternative drugs for the treatment of syphilis in pregnant women and the prevention of congenital syphilis.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"100 6","pages":"Pages 667-673"},"PeriodicalIF":2.8000,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Factors associated with signs of congenital syphilis in newborns\",\"authors\":\"Ana Fátima Braga Rocha , Maria Alix Leite Araújo , Aisha Khizar Yousafzai , Rebeca Gomes de Oliveira , Ana Patrícia Alves da Silva\",\"doi\":\"10.1016/j.jped.2024.06.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To analyze risk factors (maternal, obstetric and demographic) associated with congenital syphilis and the clinical characteristics of the newborns.</div></div><div><h3>Method</h3><div>A cross-sectional study carried out in ten public maternity hospitals in Fortaleza, Ceará, Brazil that included cases of live births reported with congenital syphilis in 2015.</div></div><div><h3>Results</h3><div>469 cases were analyzed; 199 (42.4 %) showed some sign or symptom suggestive of congenital syphilis; of these, 65 (32.7 %) were preterm, 87 (43.7 %) had low birth weight, 116 (58.3 %) had jaundice that required phototherapy, 13 (6.5 %) had hepatomegaly, 10 (5 %) had skin lesions, eight (4.0 %) had splenomegaly and one (0.5 %) had limb pseudoparalysis. Records of other clinical changes were identified in 36 (7.7 %) children. Children whose mothers were not treated or who received a drug other than penicillin and those whose mothers had a VDRL titer ≥ 1:16 at birth were 3.7 and 3.2 times more likely to be born with signs of congenital syphilis (<em>p</em> < 0.001- 95 % CI 2.41–5.58; <em>p</em> < 0.001 – 95 % CI 2.41–5.58) respectively.</div></div><div><h3>Conclusions</h3><div>The findings of this study draw attention to the importance of improving the quality of prenatal care and the development of studies aimed at finding alternative drugs for the treatment of syphilis in pregnant women and the prevention of congenital syphilis.</div></div>\",\"PeriodicalId\":14867,\"journal\":{\"name\":\"Jornal de pediatria\",\"volume\":\"100 6\",\"pages\":\"Pages 667-673\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jornal de pediatria\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0021755724000895\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jornal de pediatria","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021755724000895","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

摘要

摘要分析与先天性梅毒相关的风险因素（产妇、产科和人口统计学）以及新生儿的临床特征：在巴西塞阿拉州福塔莱萨市的10家公立妇产医院开展横断面研究，纳入2015年报告的患有先天性梅毒的活产病例：分析了469例病例，其中199例（42.4%）出现了一些先天性梅毒的体征或症状，其中65例（32.7%）为早产儿，87例（43.7%）出生体重不足，116例（58.3%）出现黄疸，需要光疗，13例（6.5%）肝脏肿大，10例（5%）皮肤病变，8例（4.0%）脾脏肿大，1例（0.5%）肢体假性瘫痪。36名儿童（7.7%）有其他临床变化记录。母亲未接受治疗或接受青霉素以外药物治疗的儿童，以及母亲在出生时VDRL滴度≥1:16的儿童，出生时出现先天性梅毒症状的几率分别为3.7倍和3.2倍（p 结论：该研究结果引起了人们的注意：这项研究的结果提请人们注意提高产前护理质量的重要性，以及开展旨在寻找替代药物治疗孕妇梅毒和预防先天性梅毒的研究的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Factors associated with signs of congenital syphilis in newborns

Objective

To analyze risk factors (maternal, obstetric and demographic) associated with congenital syphilis and the clinical characteristics of the newborns.

Method

A cross-sectional study carried out in ten public maternity hospitals in Fortaleza, Ceará, Brazil that included cases of live births reported with congenital syphilis in 2015.

Results

469 cases were analyzed; 199 (42.4 %) showed some sign or symptom suggestive of congenital syphilis; of these, 65 (32.7 %) were preterm, 87 (43.7 %) had low birth weight, 116 (58.3 %) had jaundice that required phototherapy, 13 (6.5 %) had hepatomegaly, 10 (5 %) had skin lesions, eight (4.0 %) had splenomegaly and one (0.5 %) had limb pseudoparalysis. Records of other clinical changes were identified in 36 (7.7 %) children. Children whose mothers were not treated or who received a drug other than penicillin and those whose mothers had a VDRL titer ≥ 1:16 at birth were 3.7 and 3.2 times more likely to be born with signs of congenital syphilis (p < 0.001- 95 % CI 2.41–5.58; p < 0.001 – 95 % CI 2.41–5.58) respectively.

Conclusions

The findings of this study draw attention to the importance of improving the quality of prenatal care and the development of studies aimed at finding alternative drugs for the treatment of syphilis in pregnant women and the prevention of congenital syphilis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Jornal de pediatria 医学-小儿科

CiteScore

5.60

自引率

3.00%

发文量

审稿时长

43 days

期刊介绍： Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.