Marco Andreani, Feliciana Mariotti, Anna Pira, Franco Locatelli, Giuseppe Testa, Mariarosa Battarra, Priscilla Caputi, Alessandra Scarabello, Barbara Bellei, Cristiana Di Campli, Maria Chiara Collina, Ilaria Esposito, Anna Rita Giampetruzzi, Biagio Didona, Dario Pitocco, Clara De Simone, Giovanni Di Zenzo
{"title":"意大利患者中与格列汀相关大疱性类天疱疮易感性有关的 HLA 等位基因。","authors":"Marco Andreani, Feliciana Mariotti, Anna Pira, Franco Locatelli, Giuseppe Testa, Mariarosa Battarra, Priscilla Caputi, Alessandra Scarabello, Barbara Bellei, Cristiana Di Campli, Maria Chiara Collina, Ilaria Esposito, Anna Rita Giampetruzzi, Biagio Didona, Dario Pitocco, Clara De Simone, Giovanni Di Zenzo","doi":"10.1111/tan.15616","DOIUrl":null,"url":null,"abstract":"<p>Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between <i>HLA-DQB1*03:01</i> allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: <i>DRB1*11:01</i>, <i>DRB3*02:02</i>, <i>DQA1*05:05</i>, <i>DQB1*03:01</i> or <i>DRB1*11:04</i>, <i>DRB3*02:02</i>, <i>DQA1*05:05</i> and <i>DQB1*03:01</i>. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients\",\"authors\":\"Marco Andreani, Feliciana Mariotti, Anna Pira, Franco Locatelli, Giuseppe Testa, Mariarosa Battarra, Priscilla Caputi, Alessandra Scarabello, Barbara Bellei, Cristiana Di Campli, Maria Chiara Collina, Ilaria Esposito, Anna Rita Giampetruzzi, Biagio Didona, Dario Pitocco, Clara De Simone, Giovanni Di Zenzo\",\"doi\":\"10.1111/tan.15616\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between <i>HLA-DQB1*03:01</i> allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: <i>DRB1*11:01</i>, <i>DRB3*02:02</i>, <i>DQA1*05:05</i>, <i>DQB1*03:01</i> or <i>DRB1*11:04</i>, <i>DRB3*02:02</i>, <i>DQA1*05:05</i> and <i>DQB1*03:01</i>. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.</p>\",\"PeriodicalId\":13172,\"journal\":{\"name\":\"HLA\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2024-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"HLA\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/tan.15616\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"HLA","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/tan.15616","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients
Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.
期刊介绍：
HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.
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