地高辛仍然有用，但仍会引起中毒。

IF 3.4 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Cleveland Clinic Journal of Medicine Pub Date : 2024-08-01 DOI:10.3949/ccjm.91a.23105

Alejandro Durán Crane, Michael Militello, Michael D Faulx

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引用次数: 0

摘要

地高辛是已知最古老的心血管药物，如今仍被用于治疗心力衰竭和心房颤动。由于地高辛的治疗指数较窄，且存在多种相互作用，因此经常会引起中毒症状和心律失常。更重要的是，血清地高辛水平升高与心力衰竭或心房颤动患者的死亡风险升高有关，即使没有中毒症状或体征。本文回顾了地高辛的使用现状、药理原理以及中毒的机制、临床表现和处理方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Digoxin is still useful, but is still causing toxicity.

Digoxin, the oldest known cardiovascular drug, is still used today to treat heart failure and atrial fibrillation. Because it has a narrow therapeutic index and multiple interactions, it frequently causes toxicity with a wide range of symptoms and cardiac arrhythmias. More importantly, elevated serum digoxin levels have been linked to a higher risk of death in patients with heart failure or atrial fibrillation, even without signs or symptoms of toxicity. This article reviews the current state of digoxin use, its pharmacologic principles, and the mechanisms, clinical presentation, and management of toxicity.

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来源期刊

Cleveland Clinic Journal of Medicine 医学-医学：内科

CiteScore

3.80

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The mission of Cleveland Clinic Journal of Medicine (CCJM) is to provide its readers with up-to-date, practical, clinical information relevant to internal medicine, cardiology, and related fields. Consistent with this mission, CCJM focuses on timely review articles and other content that has a continuing-education orientation rather than on original research or case reports. CCJM authors, drawn from Cleveland Clinic and other top medical institutions throughout the world, are asked to identify new findings that are changing the practice of medicine and to advise readers how to apply them in daily patient care. Authors are chosen for their experience, acquired through caring for patients, teaching other physicians, and researching clinical questions.