阿司匹林诱导的雌性大鼠青春期和生殖激素谱的改变

IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Emine Kacar, Zeynep Dila Oz, Ihsan Serhatlioglu, Nalan Kaya Tektemur, Mehmet Ridvan Ozdede, Tugce Yalcin, Gulendam Ozbeg, Aslisah Ozgen, Fatih Tan, Seval Ulku Orhan, Ozge Zorlu, Aysun Ucer, Abdullah Yasar, Bayram Yilmaz, Haluk Kelestimur
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引用次数: 0

摘要

研究目的研究每天给雌性大鼠长期服用麻黄素对其青春期和生殖系统各种参数的综合影响。本研究旨在阐明阿司匹林在调节青春期开始中的作用及其对激素谱和卵巢组织学的影响:方法:每天腹腔注射(i.p.)500 纳克/千克剂量的阿司匹林,连续注射八周。方法:每天腹腔注射(i-p)500纳克/千克,连续8周,进行荷尔蒙测定和组织学分析,以评估阿司匹林对青春期开始和生殖功能的影响:结果:每天长期服用阿司匹林可加速首次发情。激素测定显示,血清中卵泡刺激素(FSH)和雌二醇(E2)的水平显著升高,而抑制素B的水平则有所下降。组织学评估显示,卵巢组织中的初级和次级卵泡数量增加,但不影响原始卵泡数量或生殖器官重量:结论:脂肪因子在调节青春期和生殖功能方面的作用日益得到认可。本研究旨在首次全面考察每日长期服用阿司匹林对雌性大鼠青春期和生殖参数的影响。利用激素测定和组织学分析,每天腹腔注射(i.p.)500 纳克/千克剂量的阿司匹林,连续八周。我们的研究结果表明,每天长期服用阿司匹林可加速首次发情的开始。荷尔蒙检测显示,血清中的卵泡刺激素(FSH)和雌二醇(E2)水平明显升高,而抑制素B水平则有所下降。组织学评估显示,卵巢组织中的初级和次级卵泡数量增加,但不影响原始卵泡数量或生殖器官重量。这些结果为我们提供了新的视角,让我们了解到芦荟素在提高首次发情年龄和调节激素水平方面的作用,从而为女性生殖系统带来潜在的益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Asprosin-induced alterations in female rat puberty and reproductive hormonal profiles.

Objective: To investigate the comprehensive effects of daily chronic asprosin administration on various pubertal and reproductive parameters in female rats. This study aims to elucidate the role of asprosin in regulating the onset of puberty and its influence on hormonal profiles and ovarian histology.

Methods: Asprosin was administered intraperitoneally (i.p.) at a dose of 500 ng/kg daily for eight weeks. Hormonal assays and histological analyses were performed to evaluate the effects of asprosin on the onset of puberty and reproductive function.

Results: Daily chronic administration of asprosin accelerated the onset of the first oestrus. Hormonal assays revealed significant elevations in serum levels of Follicle-Stimulating Hormone (FSH) and Oestradiol (E2), while Inhibin B levels decreased. Histological evaluations demonstrated an increased number of primary and secondary follicles in ovarian tissue, without affecting primordial follicle counts or reproductive organ weights.

Conclusions: Role of adipokines in regulating puberty and reproductive function has increasingly gained recognition. This study aimed to provide the first comprehensive examination of the effects of daily chronic asprosin administration on pubertal and reproductive parameters in female rats. Utilising hormonal assays and histological analyses, asprosin was administered intraperitoneally (i.p.) at a dose of 500 ng/kg, daily, for eight weeks. Our findings revealed that daily chronic administration of asprosin accelerated the onset of the first oestrus. Hormonal assays showed significant elevations in serum levels of Follicle-Stimulating Hormone (FSH) and Oestradiol (E2), while Inhibin B levels decreased. Histological evaluations demonstrated an increased number of primary and secondary follicles in ovarian tissue, without affecting primordial follicle counts or reproductive organ weights. These results provide new insights into asprosin's role in advancing the age of first oestrus and modulating hormonal profiles, thereby offering potential benefits to the female reproductive system.

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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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