蛇咬致病疗法领域的进展与挑战。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
José María Gutiérrez, Nicholas R Casewell, Andreas H Laustsen
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引用次数: 0

摘要

每年都有数十万人被蛇咬伤致死或致残,尤其是在热带地区的农村地区。目前仍在使用动物源性抗蛇毒血清治疗蛇毒中毒,这种抗蛇毒血清避免了许多生命的丧失,但也是需要创新的药物。目前,我们正在努力改进熏蒸疗法,在优化现有抗蛇毒血清的生产和质量、加快基于单克隆抗体的重组抗蛇毒血清的研究和开发,以及重新利用阻断关键毒素的小分子抑制剂等方面都取得了可喜的进展。在此,我们回顾了这些领域的最新进展,并讨论了不同蛇咬伤治疗方法的治疗机会和局限性。最后,我们讨论了为实现世界卫生组织预防和控制蛇咬伤全球战略的目标而需要应对的与临床前和临床评估、监管途径、大规模生产以及销售和获取有关的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics.

Snakebite envenoming kills and maims hundreds of thousands of people every year, especially in the rural settings of tropical regions. Envenomings are still treated with animal-derived antivenoms, which have prevented many lives from being lost but which are also medicines in need of innovation. Strides are being made to improve envenoming therapies, with promising efforts made toward optimizing manufacturing and quality aspects of existing antivenoms, accelerating research and development of recombinant antivenoms based on monoclonal antibodies, and repurposing of small-molecule inhibitors that block key toxins. Here, we review the most recent advances in these fields and discuss therapeutic opportunities and limitations for different snakebite treatment modalities. Finally, we discuss challenges related to preclinical and clinical evaluation, regulatory pathways, large-scale manufacture, and distribution and access that need to be addressed to fulfill the goals of the World Health Organization's global strategy to prevent and control snakebite envenoming.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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