Jingyi Zhao, Chen Gao, Wenlai Guo, Boxiang Zhang, Sixu Ren, Siyu Wu, Jie Guo and Wenrui Qu
{"title":"导电水凝胶是治疗糖尿病伤口的 \"创新疗法","authors":"Jingyi Zhao, Chen Gao, Wenlai Guo, Boxiang Zhang, Sixu Ren, Siyu Wu, Jie Guo and Wenrui Qu","doi":"10.1039/D4QM00405A","DOIUrl":null,"url":null,"abstract":"<p >Diabetic wounds are one of the most serious complications of diabetes mellitus caused by neurovascular injury and microenvironmental disorders, including hyperinflammation, hypoxia, and persistent infection, requiring multiple interventions at different stages. However, the traditional treatment only targets the wound and ignores the intrinsic pathogenesis, resulting in a limited therapeutic effect. One promising option is hydrogels, which have good biocompatibility, adhesion, and plasticity. Incorporating conductive materials into hydrogels further enhances their therapeutic effects by accelerating hemostasis, promoting nerve and vascular regeneration, and enhancing the anti-inflammatory, antioxidant, and antibacterial effects, which is the future development direction for treating diabetic wounds. This review systematically analyzes the role of electricity in treating diabetic wounds and discusses the material selection and methods for the functional realization of conductive hydrogels. Furthermore, the main challenges and future perspectives in this field are discussed and prospected, aiming to fuel and foster the development of conductive hydrogels in diabetic wound therapy.</p>","PeriodicalId":86,"journal":{"name":"Materials Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Conductive hydrogels as an “innovative healer” for the treatment of diabetic wounds\",\"authors\":\"Jingyi Zhao, Chen Gao, Wenlai Guo, Boxiang Zhang, Sixu Ren, Siyu Wu, Jie Guo and Wenrui Qu\",\"doi\":\"10.1039/D4QM00405A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Diabetic wounds are one of the most serious complications of diabetes mellitus caused by neurovascular injury and microenvironmental disorders, including hyperinflammation, hypoxia, and persistent infection, requiring multiple interventions at different stages. However, the traditional treatment only targets the wound and ignores the intrinsic pathogenesis, resulting in a limited therapeutic effect. One promising option is hydrogels, which have good biocompatibility, adhesion, and plasticity. Incorporating conductive materials into hydrogels further enhances their therapeutic effects by accelerating hemostasis, promoting nerve and vascular regeneration, and enhancing the anti-inflammatory, antioxidant, and antibacterial effects, which is the future development direction for treating diabetic wounds. This review systematically analyzes the role of electricity in treating diabetic wounds and discusses the material selection and methods for the functional realization of conductive hydrogels. Furthermore, the main challenges and future perspectives in this field are discussed and prospected, aiming to fuel and foster the development of conductive hydrogels in diabetic wound therapy.</p>\",\"PeriodicalId\":86,\"journal\":{\"name\":\"Materials Chemistry Frontiers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Chemistry Frontiers\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/qm/d4qm00405a\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Chemistry Frontiers","FirstCategoryId":"88","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/qm/d4qm00405a","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Conductive hydrogels as an “innovative healer” for the treatment of diabetic wounds
Diabetic wounds are one of the most serious complications of diabetes mellitus caused by neurovascular injury and microenvironmental disorders, including hyperinflammation, hypoxia, and persistent infection, requiring multiple interventions at different stages. However, the traditional treatment only targets the wound and ignores the intrinsic pathogenesis, resulting in a limited therapeutic effect. One promising option is hydrogels, which have good biocompatibility, adhesion, and plasticity. Incorporating conductive materials into hydrogels further enhances their therapeutic effects by accelerating hemostasis, promoting nerve and vascular regeneration, and enhancing the anti-inflammatory, antioxidant, and antibacterial effects, which is the future development direction for treating diabetic wounds. This review systematically analyzes the role of electricity in treating diabetic wounds and discusses the material selection and methods for the functional realization of conductive hydrogels. Furthermore, the main challenges and future perspectives in this field are discussed and prospected, aiming to fuel and foster the development of conductive hydrogels in diabetic wound therapy.
期刊介绍:
Materials Chemistry Frontiers focuses on the synthesis and chemistry of exciting new materials, and the development of improved fabrication techniques. Characterisation and fundamental studies that are of broad appeal are also welcome.
This is the ideal home for studies of a significant nature that further the development of organic, inorganic, composite and nano-materials.