羧甲基纤维素功能化磁铁矿纳米粒子的合成与表征--作为太赫兹光谱对比剂在肿瘤学中的应用

IF 2.4 4区材料科学 Q2 CRYSTALLOGRAPHY

Crystals Pub Date : 2024-07-30 DOI:10.3390/cryst14080696

Oliver Daniel Schreiner, Petrisor Samoila, Thomas Gabriel Schreiner, Diana Socotar, Romeo Cristian Ciobanu

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引用次数: 0

摘要

本文介绍了通过共沉淀法获得羧甲基纤维素功能化磁铁矿的过程，方法是在柠檬酸中对磁铁矿进行初步稳定。磁铁矿组装体成功通过了体外和体内生物相容性测试。介质损耗因数的测量值非常高，这也是该组件可用作造影剂的先决条件。对宽带太赫兹光谱进行了分析，以确定正常细胞和癌细胞之间信号差异最相关的频段（此处为 3.2-4 太赫兹），从而确定颗粒作为太赫兹成像对比剂的潜在用途，并将其应用于肿瘤学领域。

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Synthesis and Characterization of Carboxymethylcellulose-Functionalized Magnetite Nanoparticles as Contrast Agents for THz Spectroscopy with Applications in Oncology

This paper describes a process to obtain magnetite functionalized with carboxymethylcellulose via coprecipitation by means of a preliminary stabilization of magnetite in citric acid. The magnetite assemblies successfully passed in vitro and in vivo tests of bio-compatibility. The measured values for the dielectric loss factor are remarkably high, a prerequisite for the assemblies’ potential use as contrast agents. Broadband THz spectroscopy analysis was performed to identify the most relevant frequency bands (here, 3.2–4 THz) where the signal difference between normal cells and cancer cells is relevant for the particles’ potential use as contrast agents for THz imaging, with applications in oncology.

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来源期刊

Crystals CRYSTALLOGRAPHYMATERIALS SCIENCE, MULTIDIS-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

4.20

自引率

11.10%

发文量

1527

审稿时长

16.12 days

期刊介绍： Crystals (ISSN 2073-4352) is an open access journal that covers all aspects of crystalline material research. Crystals can act as a reference, and as a publication resource, to the community. It publishes reviews, regular research articles, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Full experimental details must be provided to enable the results to be reproduced. Crystals provides a forum for the advancement of our understanding of the nucleation, growth, processing, and characterization of crystalline materials. Their mechanical, chemical, electronic, magnetic, and optical properties, and their diverse applications, are all considered to be of importance.